Teijin Limited

Nobuyuki Endo

Hiroaki Kaneko

Masaya Ito

Yukako Fukuhira

The invention is a cellulose derivative wherein some of the carboxyl groups of the cellulose derivative carboxymethylcellulose are replaced with &#x2014;CO&#x2014;NH&#x2014;X&#x2014;CO&#x2014;Y&#x2014;Z, and a hydrogel of the same. In the formula, X is a C1-10 divalent hydrocarbon group, Y is a divalent group derived from polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or &#x2014;CO&#x2014;R, where Ris a C1-23 hydrocarbon group. The hydrogel has excellent viscoelasticity and can be injected into prescribed sites with injecting devices such as syringes, and it can thus be utilized as a medical gel or adhesion barrier.

Cellulose derivative and hydrogel thereof

The invention provides a cellulose derivative having a repeating unit of the formula below, a composition including the cellulose derivative and a phospholipid, a method for production thereof, and an adhesion barrier including the cellulose derivative or the composition. In the formula, R, R, and Rare &#x2014;H, &#x2014;CH&#x2014;COOH, &#x2014;CH&#x2014;COOX, or &#x2014;CHCO-phosphatidylethanolamine, and X is an alkali metal or an alkali earth metal. The degree of substitution of &#x2014;CH&#x2014;COOH and &#x2014;CH&#x2014;COOX is 0.3 to 2.0 in total, and the degree of substitution of &#x2014;CHCO-phosphatidylethanolamine is 0.001 to 0.05.

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Hino, Japan

Nobuyuki Endo