Kyowa Hakko Kogyo Co., Ltd.

Other

Kyowa Hakko Kirin Co., Limited

Nobuyoshi Amishiro

Chikara Murakata

Shiro Akinaga

Yoji Ino

Mayumi Miyata

Tadakazu Akiyama

Takeshi Takahashi

Yukimasa Shiotsu

Shiro Soga

Harumi Ogawa

Hiroyuki Ishida

Hiromitsu Saito

Eiji Kobayashi

Katsushige Gomi

Pui-Kai Li

Satoru Nagamura

Yuichi Fukuda

Hisashi Tagaya

Taisuke Nakata

Akihiko Okamoto

Yoshinori Yamashita

Fumihiko Kanai

Ryuichiro Nakai

Tsutomu Agatsuma

Takashi Kuwabara

Junichiro Yamamoto

Yushi Kitamura

Keisuke Kimpara

Jun Funahashi

Kenichi Yasoshima

Eiichi Fuse

Kozue Muramatsu

Motoya Mie

Hiroko Takahashi

Toshiyuki Atsumi

Provided is a kynurenine production inhibitor comprising a nitrogen-containing heterocyclic compound represented by formula (I): (wherein Rand Rmay be the same or different and each represent a hydrogen atom or the like, Gand Gmay be the same or different and each represent a nitrogen atom or the like, X represents formula (III): (wherein mand mmay be the same or different and each represent an integer of 0 or 1, Y represents an oxygen atom or the like, and Rand Rmay be the same or different and each represent a hydrogen atom or the like),Rrepresents optionally substituted lower alkyl or the like, Rrepresents a hydrogen atom or the like, and Rrepresents optionally substituted lower alkyl or the like), and the like.

Kynurenine production inhibitor

The present invention provides a nitrogen-containing heterocyclic compound represented by formula (I): {wherein W represents a nitrogen atom or &#x2014;CH&#x2014;; 

Nitrogen-containing heterocyclic compound

Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I):{wherein Rand Rare the same or different and represent a hydrogen atom, a lower alkyl group or, etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a cyano group, an amino group, COR(wherein Rrepresents a substituted lower alkyl group etc.), a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, etc}, or pharmaceutically acceptable salts thereof.

Estra-1,3,5(10)-triene derivatives

Staurosporin derivatives

Estra-1,3,5(10),16-tetraene derivatives

Radicicol derivatives

Radioicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof:

Estra-1,3,5(10),16-tetraene derivatives represented by the following formula (I):

Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof:

DC-89 derivatives

Pyrrolo-indole derivatives

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Shizuoka, Japan

Nobuyoshi Amishiro