Kirin Beer Kabushiki Kaisha

Microbial Chemistry Research Foundation

Nobuyasu Komeshima

Shohachi Nakajima

Kuniaki Tatsuta

Noboru Otake

Hiroyuki Kawai

Atsuo Odagawa

Shigeyuki Mizobuchi

Disclosed is an anthracycline compound of the formula (I): ##STR1## wherein Ra is -R.sup.1, ##STR2## or --OR.sup.3, R.sup.1 being (1) alkyl, alkenyl, alkynyl, fluoroalkyl, aryl or aralkyl, or (2) alkyl, alkenyl, alkynyl. fluoroalkyl, aryl or aralkyl having carboxyl, azido, amino, hydroxy, alkoxy or a halogen atom; R.sup.2 being R.sup.1, a hydrogen atom or hydroxy; and R.sup.3, which may be the same or different when one substituent has two R.sup.3 's, being R.sup.1 or a hydrogen atom; or the formula (II): ##STR3## wherein Rb is -R.sup.1, ##STR4## or --OR.sup.3, R.sup.1, R.sup.2 and R.sup.3 being as defined above; and R.sup.4 being the same as R.sup.3 except that methyl is not included; or an acid addition salt thereof. This compound can be contained as an active ingredient in an antitumor agent, whereby good results are attainable.

3'-deamino-3'-(2'-substituted-4'-morpholino)-anthracycline compounds

Disclosed is a novel anthracycline compound of the following formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are each a hydroxyl group or a hydrogen atom and satisfy the condition that, when R.sup.2 is a hydroxyl group, R.sup.1 is a hydroxyl group or a hydrogen atom, whereas, when R.sup.2 is a hydrogen atom, R.sup.1 is a hydrogen atom, or an acid addition salt thereof. These compounds can be contained as active ingredients in antitumor agents, whereby good results are attainable.

Anthracycline compounds

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Maebashi, Japan

Nobuyasu Komeshima