Sapporo Breweries Limited

Nobuyasu Enoki

Naoki Abe

Yasukazu Nakakita

Suguru Takeo

Nobuhiro Watanabe

Ryoichi Sato

Hideaki Uchida

Disclosed are novel HP530 compounds, their derivatives or their pharmaceutically permissible salts, a process for preparing them and an antitumor substances containing them as active ingredient. The HP530 compounds and their derivatives expressed by the general formula below can be prepared by cultivating Streptomyces sp. HP530 (FERM BP-2786) or and chemically derivation. ##STR1## where X is a C.sub.2 -C.sub.4 acyl group or a hydrogen atom, Y is a C.sub.2 -C.sub.4 acyl group or a hydrogen atom and Z is a group expressed by the formula (II), (III) or (IV). ##STR2##

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Yaizu, Japan

Nobuyasu Enoki