Daiichi Sankyo Company, Limited

Nobuya Kurikawa

Keiji Saito

Osamu Iwamoto

Katsuyoshi Nakajima

Yasuyuki Ogawa

Toru Taniguchi

Kaori Ito

Eriko Kioi

Shinji Tanaka

Natsumi Nishihama

Wataru Saitoh

Momoko Ogitani

Kazumasa Aoki

Satoshi Shibuya

Tsuyoshi Mikkaichi

Seiko Nagata

Nobuyuki Ohkawa

Hiroyuki Tsuruoka

Tsuyoshi Soneda

Junya Kawai

Yuma Umezaki

Tomohiro Honda

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: A: e.g., Benzene, E: e.g., —CH—, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R, R, R: e.g., a halogen atom, R: e.g., a C1-C6 alkyl group, R: e.g., a hydrogen atom, R, R, R, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, n, n, n: e.g., 1.

Compound having cyclic structure

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R: e.g., a C1-C6 alkyl group; R: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R: e.g., a C1-C6 alkyl group.

Griseofulvin compound

An object of the present invention is to provide a compound that has a specific chemical structure having an activation effect on SIRT6 and is useful as an active component for preventing and treating inflammatory diseases, and the present invention relates to a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof,

Urea compound having substituent

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below:R: e.g., a C1-C6 alkyl group; R: a C1-C6 alkyl group;A: e.g., an oxygen atom; and R: e.g., a C1-C6 alkyl group.

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below:A: e.g., Benzene, E: e.g., &#x2014;CH&#x2014;, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R, R, R: e.g., a halogen atom, R: e.g., a C1-C6 alkyl group, R: e.g., a hydrogen atom, R, R, R, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, R: e.g., a hydrogen atom, n, n, n: e.g., 1.

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Shinagawa-ku, Japan

Nobuya Kurikawa