Chugai Seiyaku Kabushiki Kaisha

The University of Tokyo

Nissan Chemical Industries Limited

Nobuya Ishii

Kenji Morikami

Nobuo Shimma

Hatsuo Kawada

Hiroshi Sakamoto

Takashi Emura

Yoshiyuki Ono

Yoshiaki Watanabe

Hidenori Takahashi

Nobuhiro Oikawa

Eisaku Mizuguchi

Toshiyuki Tsukaguchi

Sawako Ozawa

Toshiya Ito

Noriyuki Furuichi

Hirosato Ebiike

Masami Hasegawa

Kazutomo Kinoshita

Yasuharu Kato

MinJeong Park

WooSang Hong

Kohsuke Asoh

Shojiro Kadono

Haruhiko Sato

Kazuhiko Ohrai

Takuya Shiraishi

Yoshiyuki Suzuki

Masahiro Sakaitani

Jun Ohwada

Fumio Watanabe

Takanori Shimizu

Keishi Hayashi

Masateru Ohta

Masataka Minami

Mitsuaki Nakamura

Koji Toyama

Michiaki Adachi

Kohei Koyama

Miyuki Yoshida

Shun Yamamoto

Masakazu Sugiyama

Yasuhiro Tamaki

A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: 

Tetracyclic compound

The present invention provides a compound represented by the formula (1):  

Heteroarylphenylurea derivative

It is intended to provide a compound represented by the formula (1): [wherein Ar is an arylene group to be attached selected from the following formula (2): (wherein * represents a binding site to a nitrogen atom and ** represents a binding site to T); T represents &#x2014;(O)&#x2014;R; R represents a C-Calkyl group or the like; n represents 0 or 1; X represents O or the like; R, Rand Rare independently selected from a hydrogen atom or C-Calkyl; or Rand Rmay join together with an urea structure containing the nitrogen atoms to which they bind to form a 5- or 6-membered heterocycle; Y represents CH or N], or a pharmaceutically acceptable salt thereof or a prodrug thereof and a pharmaceutical composition containing the same.

Pyrazolopyridine and pyrrolopyridine multikinase inhibitors

A drug is provided that is useful as a preventive or therapeutic for cancer as a result of having superior PI3K inhibitory effects as well as superior stability in the body and water-solubility. A compound, or pharmaceutically acceptable salt thereof, represented by formula (I): [wherein, X represents a single bond, etc.; Y represents a single bond, etc. (provided that X and Y are not simultaneously single bonds); Z represents a hydrogen atom, etc.; m represents an integer of 1 or 2; and Rrepresents a cyclic substituent].

Pyrimidine derivatives as PI3K inhibitor and use thereof

The present invention provides novel &#x3b1;-amino acid derivatives of formula (1): (wherein, R, R, R, R, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have &#x3b2;ARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.

&#x3b1;-amino acid derivatives and medicaments containing the same as an active ingredient

Growing community of inventors

Kamakura, Japan

Nobuya Ishii