Kyoto University

Arkray, Inc.

Nobuya Inagaki

Hiroyuki Kimura

Hideo Saji

Kentaro Toyoda

Konomu Hirao

Hirokazu Matsuda

Kenji Nagakawa

Yasushi Kondo

Kenji Osafune

Taro Toyoda

Asami Kon

Yu Ogawa

Mikako Ioroi

A peptide that can be used as an imaging probe for GLP-1R is provided. In an embodiment, a polypeptide is represented by the following formula (3); 

Polypeptide and imaging method

Provided is a method for inducing pancreatic hormone-producing cells from pancreatic progenitor cells efficiently. The method comprises a step of culturing the cells in a culture medium comprising sodium cromoglicate.

Method for generating pancreatic hormone-producing cells

A new peptide derivative is provided. The peptide derivative is represented by the following general formula (I), where polypeptide ExP is polypeptide that contains completely or partially the amino acid sequence of exendin-4, and a -L-Z group represents a group represented by the following formula (II) that is bonded to an amino acid side chain of or the &#x3b1;-amino group at the N-terminus of the polypeptide ExP, 

Peptide derivative and use of the same

A molecular probe for imaging of pancreatic islets is provided. The molecular probe includes a polypeptide represented by the following formula (1), or a polypeptide that has a homology with the foregoing polypeptide. Wherein 'X' represents a lysine residue, an amino group of a side chain of the lysine residue being labeled with a group represented by the following chemical formula (I), wherein A represents an aromatic hydrocarbon group or an aromatic heterocyclic group; Rrepresents a substituent that containsC,N,O,F,Cu,Ga,Ga,Br,Br,Br,Tc,In,I,I,I, orI; Rrepresents either a hydrogen atom, or a substituent different from that represented by R; and Rrepresents any one of a bond, an alkylene group having 1 to 6 carbon atoms, and an oxyalkylene group having 1 to 6 carbon atoms.

Molecular probe for imaging of pancreatic islets and use of the same

A precursor of a molecular probe for imaging of pancreatic islets is provided. The precursor includes a polypeptide represented by any one of the following formulae (1) to (12), or a polypeptide having a homology with the foregoing polypeptide: 

Molecular probe precursor for imaging of pancreatic islet, and use thereof

A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe comprises a polypeptide represented by the following formula (1), (2), or (3), or a polypeptide having homology with the foregoing polypeptide, where, in the formulae (1) and (2), 'X' represents a lysine residue, an amino group of a side chain of the lysine residue being labeled with a radioactive nuclide, and 'Z&#x2014;' indicates that an &#x3b1;-amino group at an N-terminus is not modified, or is modified with a modifying group having no electric charge; in the formula (3), &#x201c;B&#x2014;&#x201d; indicates that an &#x3b1;-amino group at an N-terminus is labeled with a radioactive nuclide; and in the formulae (1), (2), and (3), &#x201c;&#x2014;NH&#x201d; indicates that a carboxyl group at a C-terminus is amidated.

To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides: polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides: where X in the formulae (1) and (5) and B- in the formula (9) indicate that an amino group is labeled with a group represented by the formula (I) below having an aromatic ring, wherein A represents either an aromatic hydrocarbon group or an aromatic heterocyclic group, Rrepresents a substituent that contains radioactive iodine, Rrepresents either a hydrogen atom or a substituent different from that represented by R, and Rrepresents any one of a bond, a methylene group, and an oxymethylene group.

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Kyoto, Japan

Nobuya Inagaki