Nippon Shinyaku Company, Ltd.

Takara Shuzo Co., Inc.

Nobutoshi Ojima

Yoshiaki Yoshikuni

Yoji Ezure

Kiyotaka Konno

Hiroshi Enomoto

Teruya Nakamura

Yoshiaki Aoyagi

Makoto Sugiyama

Kazuya Mori

Shingo Matsumura

Masahiro Yagi

Masanobu Kawamata

Takayuki Ozaki

Shigeaki Maruo

Shingo Matsumura, Deceased

Hideyuki Yasuda

Takashi Seto

Manabu Itoh

Compounds are described which are useful for lowering the activity of .alpha..sub.2 -PI, for the treatment of myocardial infarctions and cerebral infarctions, as urokinase secretion accelerators, as antithrombotic agents and to accelerate the fibrinolysis accelerating effect.

Therapeutic agents

2-amino-2-deoxy-D-mannitol is produced from a microorganism strain of the genus Streptomyces or a mutant strain thereof in improved yields and purity.

Method for manufacturing 2-amino-2-deoxy-D-mannitol

Compounds of formula I are useful in the prophylaxis or treatment of hyperglycemic symptoms ##STR1## wherein R is alkyl substituted by one or more hydroxy.

Glucosylmoranoline derivatives and use thereof for inhibiting increase

A compound of the formula (I): ##STR1## in which:  is a single bond or a double bond,

Physiologically active substances named SEN-366

Bisglucosyl moranoline of the formula (I) ##STR1## is useful in inhibiting increase of blood sugar in sugar-loaded animals and humans, and particularly for treatment of diabetes mellitus.

Moranoline derivatives

Moranolines are produced which are useful for controlling blood sugar levels.

Moranoline derivatives and process for preparation thereof

Growing community of inventors

Moriyama, Japan

Nobutoshi Ojima