Other

Ghen Corporation

Nisshin Pharma Inc.

Nobutake Kimura

Yoshikatsu Kodama

Faustino C Icatlo, Jr

Masato Ariga

Faustino C Icatlo

An inhibitor of colonization in the stomach comprises as an active ingredient a glycoprotein which specifically binds to urease. This glycoprotein is isolated and purified from a glycoprotein-containing substance, especially that derived from bovine milk whey or albumen of chicken eggs by affinity chromatography using a column on which urease is immobilized. The glycoprotein is able to effectively inhibit colonization, so is useful for the prevention or treatment of diseases caused by infection of such as peptic ulcers. A food and medicament comprising the inhibitor are also provided.

Glycoprotein having inhibitory activity against helicobacter pylori colonization

An inhibitor composition of adhesion in the stomach comprises (1) anti-urease antibodies obtained from eggs laid by hens which have been immunized against urease and (2) an inhibitor of gastric acid secretion. This inhibitor is capable of completely eliminating from the stomach, so it is useful for the prevention or treatment of diseases caused by infection of such as peptic ulcers.

Pharmaceutical composition useful in the treatment of peptic ulcers

The present invention provides specific antibodies obtained from eggs laid by hens which have been immunized against urease of as an antigen, and specific antibodies obtained from eggs laid by hens which have been immunized against flagella of as an antigen. These antibodies are useful for the prevention or treatment of gastritis, gastric ulcers and duodenal ulcers caused by infection of . At least one organism selected from lactic acid bacteria, Enterococcuses, yeasts, and Baillus can be used along with the antibodies.

Specific antibodies for use in preparation of pharmaceutical compositions useful in the prevention or treatment of gastritis, gastric ulcers and duodenal ulcers

The present invention provides a safe and effective inhibitor of,colonization in the stomach and a food containing the inhibitor. The inhibitor of the present invention comprises as an active ingredient a mucin, especially a mucin from milk of a cow or a mucin from albumen of an egg and is useful for the prevention or treatment of diseases caused by infection of,such as peptic ulcers.

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Saitama, Japan

Nobutake Kimura