Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Kaneka Corporation

Other

Nobutaka Tani

Fumiyasu Hirai

Eiji Ogino

Takashi Asahi

Shigeo Furuyoshi

Kazuhiko Inoue

Takehisa Matsuda

Yoshiaki Yano

Shigeki Masuda

Takamune Yasuda

Tetsuya Kawasaki

Koji Iritani

Katsuhiko Isayama

Junji Takase

Michio Nomura

Osamu Odawara

Tsuneo Hayashi

Tetsuo Mita

Hirokazu Nakanishi

Hiroshi Matsumoto

Kazuhiko Katayama

Satoshi Takata

Kazuo Suzuki

Michikazu Ohnishi

Tsutomu Okuyama

Masahiko Nishigaki

Takashi Funahashi

Hirofumi Maeda

Takashi Sugawara

Hiroyuki Maruyama

Takahisa Nakai

Kensuke Kondo

Hirotazu Nakanishi

Ryuichi Yokohari

Minoru Nishizawa

Akira Ohtani

Yuji Okubo

Makiko Kinoshita

Shinichi Aotsuka

Takayuki Sakogawa

Hiroyuki Watanabe

Toshihide Fujii

Youko Nagano

An adsorbent or bradykinin comprising styrene-divinylbenzene copolymer having sulfonic acid groups and a method for adsorbing and removing bradykinin comprising contacting the adsorbent with a fluid containing bradykinin are provided. An adsorber for adsorbing bradykinin in which the adsorbent is charged in a vessel having an inlet and an outlet for a fluid is also provided.

Adsorbent for bradykinin, method for eliminating the same by adsorption, and adsorber

An adsorbent for toxic shock syndrome toxin-1 (TSST-1) comprising a compound which has a log P value of at least 2.50 wherein P is a partition coefficient in an octanol-water system and which is immobilized on a water-insoluble carrier; a method for removing TSST-1 body fluids by adsorption which comprises bringing a body fluid containing TSST-1 into contact with the adsorbent; an adsorber for TSST-1 comprising an adsorbent packed in a container having an inlet and an outlet for a body fluid and a means for preventing the adsorbent from flowing out of the container; and use of the adsorbent. TSST-1 in body fluids can be efficiently removed by the adsorbent.

Method for removing toxic shock syndrome toxin-1 in body fluids by adsorption

Adsorbent for immunoglobulins and complexes thereof, adsorption method,

An endotoxin adsorption system of the present invention comprises a combination of a cation exchange resin having sodium as a counter ion and a cation exchange resin having sodium and one or more metal ions other than sodium as a counter ion, and adsorbs an endotoxin without decreasing of the concentration of cations.

Endotoxin adsorption system

The present invention relates to an adsorbent being capable of efficiently removing tumor necrosis factor-.alpha. (TNF-.alpha.) in a body fluid, an adsorber using the adsorbent and a process for adsorbing and removing TNF-.alpha., namely an adsorbent of TNF-.alpha., wherein onto a water-insoluble carrier a compound having a functional group represented by the formula (I): ##STR1## wherein X.sup.- is an anionic functional group, A is a substituent group except for the anionic functional group, n is an integer of 0 to 4 and in case n is at least 2, groups A, the number of which is n, may be the same or different from each other; a process for adsorbing and removing TNF-.alpha., which comprises coming the adsorbent into contact with a body fluid; and an adsorber for adsorbing TNF-.alpha. wherein a vessel having an inlet and an outlet for a body fluid and being equipped with a means for preventing the adsorbent from flowing to the outside of the vessel, is charged with the adsorbent.

Process for adsorbing and removing tumor necrosis factor-.alpha.

An adsorbent for a serum amyloid protein, which comprises a water-insoluble carrier and either a compound selected from the group consisting of a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, said compound being immobilized onto said carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, said group being bonded to said carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.

Adsorbent for serum amyloid protein

Adsorbent of interleukins, process for removing the same, and adsorber

Method for immobilizing ligand or compound having ligand bonded thereto

A polyester represented by the following general formula (I) and a copolymer which comprises two structural units represented by the following general formulae (I') and (II). ##STR1## and a coating material for use in large intestine-selective drug release pharmaceutical preparations, which contains the above polyester and/or copolymer. The polyester and copolymer of the present invention contain a saccharide residue which is hydrolyzed and/or assimilated specifically in the large intestine, drugs contained in solid oral pharmaceutical administration pharmaceutical preparations coated with the coating material of the present invention are not decomposed or absorbed by digestive organs other than the large intestine, but instead are released selectively and therefore in a high concentration in the large intestine.

Adjuvant for pharmaceutical preparations

Adsorbent having a terminal hydrazine group and a method for removing

A device for controlling cell arrangement having a pattern composed of a cell adhesive surface and a cell non-adhesive surface, which has a good selectivity of cell adhesion and which can provide a fine pattern of cells in high resolution by culturing cells in a usual manner. The device is prepared by a process which comprises applying a photosensitive, cell adhesive or cell non-adhesive polymer to a surface having a reverse cell adhesivity property to that of the applied polymer, and patternwise irradiating a light to the photosensitive polymer layer followed by development; a process which comprises patternwise irradiating UV or radiation to a cell non-adhesive surface to produce a cell adhesive functional group such as carboxyl group or amino group in the irradiated portion; or a process which comprises patternwise irradiating UV or radiation to a cell adhesive or non-adhesive surface made of plastics to produce a polymerization initiation site in the irradiated portion, and graft-polymerizing at least one monomer having the reverse cell adhesivity property to the plastic surface to produce a polymer on the irradiated portion of plastic surface.

Control of cell arrangement

A method for inhibiting decomposition and/or degradation of an implantation polymeric material in the living body, which comprises allowing dipyridamole and/or a salt or a derivative thereof as an active component to exist in the vicinity of an implantation polymeric material implanted in the living body; an inhibitor effective for inhibiting biological decomposition and/or degradation of a polymeric material implanted in the living body, which comprises dipyridamole and/or a salt or a derivative thereof as an active component; and an implantation polymeric material which contains dipyridamole and/or a salt or a derivative thereof as an active component.

Method for inhibiting biological degradation of implantation polymeric

An adsorbent for an autoantibody or immune complex produced by combining an autoantibody with its homologous antigen, which comprises a water-insoluble porous material and a compound having an anionic functional group immobilized onto said material, an apparatus for removing an autoantibody or immune complex thereof using the above-mentioned adsorbent and a method for removing an autoantibody or immune complex thereof from body fluid by passing body fluid through the above-mentioned removing apparatus. According to the present invention, the autoantibody or immune complex thereof can be selectively removed from body fluid without removing useful components in body fluid.

Autoantibody adsorbent and apparatus for removing autoantibodies using

Growing community of inventors

Osaka, Japan

Nobutaka Tani