Nippon Chemiphar Co., Ltd.

Nobutaka Mochizuki

Toshihiro Takahashi

Tomio Yamakawa

Shogo Sakuma

Shinichi Yoshida

Kunio Kobayashi

Atsushi Tendo

Takashi Kanda

Seiichiro Masui

Tsuyoshi Endo

Compounds of the general formula (I) or salts thereof and activators of PPAR&dgr; (peroxisome proliferator activated receptor &dgr;) containing the compounds or the salts as the active ingredient: wherein R and R each are hydrogen, C alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X and X are each a free valency, oxygen, S(O) (wherein p is an integer of 0 to 2), C(&boxH;O), C(&boxH;O)NH, NHC(&boxH;O), CH&boxH;CH, or the like; Y is optionally substituted C alkylene; Z is oxygen or sulfur; R and R are each optionally substituted C alkyl; and R is hydrogen or C alkyl, with the proviso that when X is a free valency, X is not O or S(O) , while when X is C(&boxH;O)NH, X is not a free valency.

PPAR delta activators

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Chiba, Japan

Nobutaka Mochizuki