Nippon Chemiphar Co., Ltd.

Nobutaka Mochiduki

Tadashi Kobayashi

Tomio Yamakawa

Shinichi Yoshida

Kunio Kobayashi

Yoriko Shinohara

Shogo Sakuma

Masatoshi Ushioda

Atsushi Tendo

Seiichiro Masui

Rie Takahashi

A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPAR&#x3b4;. 

Activating agent for peroxisome proliferator activated receptor &#x3b4;

The invention relates to compounds of the following formula (I) or their salts: in which Ris a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; Ris cyano, nitro, or the like; Ris hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.

Substituted 1,3-thiazolo[5,4-d]pyrimidines as xanthine oxidase inhibitors

The invention relates to compounds of the following formula (I) or their salts: in which Rrepresents ORor others, in which Ris an alkyl group having 1-8 carbon atoms which may have a substituent or the like; Ris halogen, nitro, cyano, carboxyl, or the like; Ris hydrogen, halogen, hydroxyl, amino, carboxyl, or the like; X is NR, oxygen, or sulfur, in which Ris hydrogen, or an alkyl group having 1-8 carbon atom which may have a substituent; and each of Y and Z is CRor nitrogen, in which Rhas the same meaning as Rabove, and a xanthine oxidase inhibitor containing the compound as an active ingredient.

Substituted thiazolopyrimidines as xanthine oxidase inhibitors

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Chiba, Japan

Nobutaka Mochiduki