Taisho Pharmaceutical Co., Ltd.

Nobutaka Hattori

Takeshi Kuwada

Daisuke Wakasugi

Naoki Miyakoshi

Tomoko Ishizaka

Youichi Shimazaki

Mitsukane Yoshinaga

Shin-ichi Shirokawa

Shin-Ichi Shirokawa

Ryo Suzuki

Hiroki Urabe

Norikazu Otake

Aya Futamura

Hideaki Tabuse

Koreaki Imura

Takaaki Matsubara

Ryo Kinoshita

Provided is a novel process for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative. More specifically, provided is a process for producing a (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative represented by formula (1): 

Method for producing (2S)-2-[(1H-pyrazol-1-yl)methyl]-1,3-oxazinane derivative

The present invention provides agents for treating or preventing diseases such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, alopecia, and so forth. Specifically, the invention provides azole derivatives represented by general formula (I), or pharmaceutically acceptable salts thereof that have an antagonistic action against the arginine-vasopressin (AVP) V1b receptor: 

Azole derivative

The present invention provides a 1,2,4-triazolone derivative represented by Formula (1A) having an antagonistic activity on the arginine-vasopressin 1b receptor or a pharmaceutically acceptable salt thereof and provides a pharmaceutical composition comprising the compound or the salt as an active ingredient, in particular, a therapeutic or preventive agent exhibiting favorable pharmacokinetics in a disease such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, or alopecia. 

1, 2, 4-triazolone derivative and use thereof as an antagonist on the arginine-vasopressin 1B receptor

Growing community of inventors

Tokyo, Japan

Nobutaka Hattori