Sumitomo Chemical Company, Limited

Sumika Fine Chemicals, Co.,ltd.

Daiichi Pharmaceutical Co., Ltd.

Nobushige Itaya

Nobuo Ohno

Takashi Matsuo

Toshio Mizutani

Kiyoshi Sugi

Masachika Hirano

Tadashi Katsura

Yoshitoshi Okuno

Tetsuya Shintaku

Isao Ohno

Kozo Matsui

Keimei Fujimoto

Shigeyoshi Kitamura

Osamu Magara

Tadashi Ohsumi

Masami Igi

Yoshihiro Kawada

Toshio Nishioka

Hisami Takeda

Shigeya Yamazaki

Taro Ishibashi

Yayoi Tagami

Teiji Yamaoka

Yoshihide Umemoto

Masahide Tanaka

Hiroshi Maeda

Fumio Fujita

Hiroshi Shiratani

Yositosi Okuno

Mitsuhiro Iwasaki

Noritada Matsuo

Ichiki Takemoto

Fukashi Horiuchi

Hiroshi Kishida

Kazunori Tsushima

Takashi Kato

Toshihiko Yano

Makoto Hatakoshi

Kiyoshi Kasamatsu

Masanao Matsui

Tadashi Mizuno

Yuki Sato

Kohichi Aketa

Mikio Sasaki

Akio Higo

Yoshitaka Ume

Ryuhei Wakita

Hajime Hirai

Yusuke Yukimoto

Toshiko Honda

Hideto Miyamoto

Hiromi Suga

Isao Ono

Toshiko Nishijima

Tsukusa Yamada

Takashi Namba

Asako Kubo

Provided is a method capable of industrially producing optically active (S)-7-hydroxy-6-methylheptan-2-one and its precursor simply and efficiently. The production method, allows a R-body preferentially hydrolyzablemicroorganism-derived esterase to act on a 2-methyl-6-oxoheptanoate (II), to produce an optically active (S)-2-methyl-6-oxoheptanoate (III).

Method of producing optically active (S)-7-hydroxy-6-methylheptan-2-one and precursor thereof

The present invention provides a method of crystallization of bicalutamide comprising adding an acetone solution containing bicalutamide to water; crystals of bicalutamide wherein particle size distribution of the crystals is 1 to 10 &#x3bc;m of Dp, 10 to 25 &#x3bc;m of Dpand 25 to 100 &#x3bc;m of Dp, and the crystals are obtainable by the method described above; and crystals of bicalutamide, wherein particle size distribution of the crystals is 1 to 3 &#x3bc;m of Dp, 2 to 5 &#x3bc;m of Dpand 5 to 15 &#x3bc;m of Dp.

Method of crystallization of bicalutamide

The present invention provides a process for producing tolterodine of the formula (1) or its salt, which comprises a step reacting a compound of the formula (2) with a base to obtain a reaction product; a step reacting the reaction product with a compound of the formula (3) to obtain a compound of the formula (4); and a step eliminating the protective group from the compound of the formula (4), and also provides a process for producing the compound of the formula (3). 

Process for producing tolterodine

The present invention relates to a crystal of bicalutamide having a defined form, as well as economical and industrially practical production methods of bicalutamide and a crystal thereof, which are superior in environmental benignity and safety. Accordingly, the present invention provides a production method of bicalutamide represented by the formula (I): which includes at least a step of reacting a compound represented by the formula (3): with an oxidizing agent, a production method of a crystal of bicalutamide, as well as a crystal form of bicalutamide as defined by X-ray diffraction (XRD) or solidC NMR measurement.

Crystal of bicalutamide and production method thereof

The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII)wherein Ris 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.

Production method of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid C1-6 alkyl ester

Process for preparing a piperidine derivative

Synthetic intermediate for epothilone derivative and production method thereof

Production method of (R)-3 hydroxy-3-(2-phenylethyl) hexanoic acid and intermediate thereof

Production methods of imidazole compound and salt thereof and intermediates therefor

Piperidine derivative and process for preparing the same

Production method of hydrazine derivative

A process for preparing tert-butyl 4&prime;-methyl-2-biphenylcarboxylate characterized in that 4&prime;-methyl-2-biphenylcarboxylic acid is reacted with isobutene in the presence of an acid catalyst. According to the present invention, tert-butyl 4&prime;-methyl-2-biphenylcarboxylate having high quality can be conveniently and industrially advantageously prepared in a high yield under mild reaction conditions such as ambient temperatures without complicated procedures or any hazardous solvents.

Process for producing tert-butyl 4&prime;-methyl-2-biphenylcarboxlate

Method for producing hydrazine derivative

Growing community of inventors

Osaka, Japan

Nobushige Itaya