Mochida Pharmaceutical Co., Ltd.

Hokkaido University

Yasuyuki Kunihiro

Ryo Tanaka

Nobuo Ohzawa

Akio Uemura

Ei Mochida

Michio Ichimura

Norimasa Iwasaki

Akio Minami

Tatsuya Igarashi

Daisuke Kawamura

Yasuhiko Kasahara

Mariko Imai

Fumiyoshi Kasahara

Chihiro Miyajima

Tsutomu Satoh

Yutaka Kato

Kiyoshi Mizuguchi

Shuhei Ohnishi

Kazuyuki Matsuura

Atsushi Sukegawa

Yasuhiro Nakai

Daisuka Kawamura

A novel composition for regenerating a cartilage has been demanded, which can achieve a good effect of regenerating a hyaline cartilage that is a nearly normal cartilage without requiring the use of any transplanted cell. The present invention provides a composition for regenerating a cartilage, wherein (a) a monovalent metal salt of low endotoxin alginic acid and (b) SDF-1 are used in combination.

Method for regenerating cartilage comprising applying a monovalent metal salt of alginic acid and SDF-1

The present invention provides a composition for regenerating cartilage or treating a cartilage disease containing a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for regenerating cartilage that improves cartilage regenerative action and ease of application to a cartilage injury lesion, and a composition for treating a cartilage disease, which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing a cartilage injury lesion, and inhibiting inflammation and pain of joint tissue.

Method for regenerating hyaline cartilage

Compositions and methods for treating cartilage disease

The present invention provides compositions and methods for treating a joint disease containing as an active ingredient thereof a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for treating a joint disease which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing cartilage injuries, suppressing inflammation and pain of joint tissue, inhibiting degeneration of synovial tissue, and inhibiting osteochondral destruction.

Composition for treating arthritic disorder

This invention provides novel benzimidazole derivatives represented by the formula (I); a process for producing the same; a drug containing at least one of such compounds as its active ingredient, in particular, a drug for preventing and/or treating diseases exhibiting eosinophilia, bronchial asthma and allergic diseases; and an enhancer for IFN-&ggr; production, and in particular, an antitumor agent or an antiviral agent based on the action of enhancing the IFN-&ggr; production which exhibits excellent oral bioavailability.

Benzimidazole derivatives

This invention relates to a novel anticoagulant substance in human urine, a process for its preparation and a pharmaceutical composition comprising the said substance for the prevention and/or treatment of diseases related to the disorders in blood coagulation system.

Anticoagulant substance obtained from urine

This invention relates to a novel glycoprotein with anticoagulant activity in human urine, a process for its preparation and a pharmaceutical composition comprising the said glycoprotein for the prevention and/or treatment of diseases related to the disorders in the blood coagulation system.

Anticoagulant substance obtained from urine and process for the

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Tokyo, Japan

Nobuo Ohzawa