Kazusa Dna Research Institute

Other

Chugai Seiyaku Kabushiki Kaisha

Chugai Sieyaku Kabushiki Kaisha

Astellas Pharma Gmbh

Nobuo Nomura

Takahiro Nagase

Osamu Ohara

Shin-Ichi Funahashi

Shoji Miyata

Kouichi Nishimura

Satoshi Nakagawa

Tatsunari Nishi

Tetsuro Kuga

Mikiko Sakurada

Kunitake Abe

Noboru Yamaji

Ayako Kawabata

Tetsuyoshi Ishiwata

Shigemasa Sawada

Masami Takei

A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.

Antibodies to brain specific membrane protein

Gene encoding brain specific membrane protein

A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ protein binding motif.

Gene encoding brain-specific membrane protein

The present invention relates to a novel protein isolated from the leukocyte of IgA nephropathy patients, and DNA encoding the protein. It also relates to an oligonucleotide based on the nucleotide sequence complementary with the DNA, an antibody which specifically reacts with the protein and, furthermore, diagnostic and therapeutic drugs of IgA nephropathy comprising it.

DNA encoding IGA nephropathy indicating protein

This invention provides a novel metalloprotease having an aggrecanase activity which causes joint diseases, a gene coding for this metalloprotease, a promoter of the above metalloprotease, a method for screening a drug with the use of the above metalloprotease and a pharmaceutical composition for inhibiting degradation of proteoglycans, which comprises as the active ingredient a substance capable of inhibiting the aggrecanase activity of the above metalloprotease.

Metalloprotease having aggrecanase activity

Growing community of inventors

Chiba, Japan

Nobuo Nomura