Eisai Company, Limited

Nobuo Niikawa

Masahiko Tsujii

Keizo Takayanagi

Shigeharu Nochi

Katsuya Tagami

Hirofumi Kuroda

Akio Kayano

Sulfoxide compounds and acetone complexes, and a process for producing the same

Processes for preparing sulfoxides useful as drugs such as acid secretion inhibitors or antiulcer drugs or intermediates for the preparation of drugs in high yields, at high purities, and with safety. Specifically, a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with a peroxoborate salt in the presence of an acid anhydride or a metal catalyst; and a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with an N-halosuccinimide, 1,3-dihalo-5,5-dimethyl-hydantoin or dichloroisocyanuric acid salt in the presence of a base. In said formulae R,is hydrogen, methoxy or difluoromethoxy; R,is methyl or methoxy; R,is 3-methoxypropoxy, methoxy or 2,2,2-trifluoroethoxy; and R,is hydrogen or methyl

Process for the preparation of pyridine derivatives

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Chiba, Japan

Nobuo Niikawa