Other

Mitsui Petrochemical Industries, Ltd.

Nof Corporation

Asahi Kogaku Kogyo Kabushiki Kaisha

Kuraray Co., Ltd.

Medtronic, Inc.

Sun Medical Co., Ltd.

Japan Science and Technology Corporation

Pola Chemical Industries, Inc.

Biocompatibles Limited

Mitsui Sekiyu Kagaku Kogyo Kabushiki Kaisha

Nakabayashi, Nobuo

Nobuo Nakabayashi

Kazuhiko Ishihara

Eiichi Masuhara

Takashi Yamamoto

Yasukazu Saimi

Junichi Yamauchi

Ken Suzuki

Kyoichiro Shibatani

Kenshiro Shuto

Tooru Wada

Patrick T Cahalan

Masami Arata

Eric J Fogt

Yasumi Koinuma

Takeo Matsumoto

Harumi Tanaka

Daijiro Shiino

Edouard Koulik

Kazuo Matsuyama

Kazunori Waki

Nobuharu Nakada

Morio Takeyama

Larik Vincent

Shozo Koshikawa

Takeshi Sakashita

Akio Hayashi

Tetsuro Ogawa

Mitsuo Nakamura

Takeshi Ichitsuka

Masahide Inoue

Yoshishige Murata

Shinji Tanaka

Nobuyuki Yamamoto

Yasuhiko Hirayama

Narimichi Honda

Hiroki Fukui

Toru Kinoshita

Koji Kamenosono

Hideo Kuroda

Tatsumichi Takeda

Kazuo Imamura

Ai Kano

Sayuri Ohkura

Masao Shaku

Katsuhisa Nagata

Tateki Kitaoka

Osamu Minoo

Shinji Miyazaki

A modified hollow-fiber membrane which has improved surface hydrophilicity without increasing the amount of components released therefrom, is less apt to interact with living-body components, does not adsorb proteins, and is less apt to deteriorate in performance. The hollow-fiber membrane has a copolymer of 2-methacryloyloxyethylphosphorylcholine and other polymerizable vinyl monomer held on a surface of the membrane, the copolymer being present on the surface in a higher concentration than in other parts of the membrane. The modified hollow-fiber membrane is useful in medical applications such as hemodialysis and blood filtration and in the medical industry, food industry etc.

Modified hollow-fiber membrane

Medical materials and process for producing the same

A wound-covering agent containing a polymer having a group represented by formula (I) (wherein R , R and R are the same or different and each represents hydrogen atom or C alkyl, and m is an integer of 2 to 4); a wound-covering material containing the preparation; and a method of wound healing which comprises the step of covering the wound of a subject with the wound-covering material to protect the wound.

Wound-covering preparation, wound-covering material, and method of wound healing

A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.

Implantable medical device

Method for making biocompatible medical article

Solubilizers, emulsifiers and dispersing agents having the effects of moisturizing the skin when used as washing agents and having the character of elevating the concentration of a material to be solubilized, emulsified or dispersed in solvents including water as compared with the case where the material is employed alone, or elevating the apparent concentration of a material to be emulsified or dispersed in solvents by increasing homogeneity of the emulsion or dispersion which contain as the active ingredient polymers obtained by polymerizing monomer compositions containing at least one hydrophilic monomer (a) having a group represented by general formula (1) in the side chain, wherein R,, R,and R,represent each H or C1-4 alkyl.

Solubilizers, emulsifiers and dispersants

A method for producing an aqueous solution of a polymer having a phosphorylcholine group in which a polymerizable composition containing a polymerizable monomer having the phosphorylcholine group represented by the formula (1) is polymerized in the presence of a non-metal polymerization initiator soluble in a water-containing medium, to obtain a crude polymer aqueous solution, and the crude polymer aqueous solution is purified with a separation membrane, and an aqueous solution of the polymer having the phosphorylcholine group obtained by the method and having not more than 2000 ppm of impurities.

Method for producing aqueous solution of polymer having phosphorylcholine groups

Polymer material, medical material and liquid high molecular composition

Dental composition for dentin hypersensitivity

There is provided a dental composition for relieving dentin hypersensitivity comprising (A) an aqueous emulsion component which contains, as emulsion particles, polymer particles having a diameter smaller than that of a dentinal tubule and forming an agglomerate larger than the diameter of a dentinal tubule when they react with a calcium compound, and (B) a water-soluble organic acid component or a water-soluble salt component thereof, a calcium salt of the organic acid being insoluble or hardly soluble in water. Using this composition, dentinal tubules open to the surface of dentin are occluded to relieve dentin hypersensitivity immediately and lastingly.

Dental composition for relieving dentin hypersensitivity

Method of producing anti-thrombogenic material and material produced

An emulsion of a polymer, in which the polymer comprises (a) a recurring unit derived from a (meth)acrylate and (b) a recurring unit derived from a vinyl compound having a group of --SO.sub.3 R in which R is a hydrogen atom, an alkali metal atom or ammonium ion. The emulsion forms a film on an adherend to decrease the infiltration into the adherend, exhibits an adhesion force to a hydroxyapatite structure, a cement, a metal or a mineral when it is applied thereto to form a film by only drying around room temperature without washing it with water, and exhibits excellent affinity to a radical-polymerizable acrylic resin composition.

Emulsion of polymer having (meth)acrylate unit and adhesive compositions

The cosmetic composition of this invention which is a 2-methacryloyloxyethylphosphorylcholine polymer (Poly MPC) in a preferable amount of 0.001% to 10% by weight based on the total weight of the cosmetic composition. The cosmetic composition can repair damage to the skin and hair, such as dryness, loss of luster, etc. and enhance the moisture preservation capability thereof. It also has a good feel when applied.

Cosmetic composition with choline derivative

A diester monomer is represented by the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 represent a hadrogen atom, an alkoxy, alkenyloxy or hydroxyalkyloxy carbonyl group having 1 to 20 carbon atoms, or a phosphorylcholine derivative ##STR2## where Y denotes --(CH.sub.2)n, --(CH.sub.2 CH.sub.2 O).sub.n CH.sub.2 CH.sub.2 -- ##STR3## n denotes 1 to 8, m is an integer of 0 or 1, R.sub.4, R.sub.5 and R.sub.6 denote an alkyl or aryl group having 1 to 8 carbon atoms, or a hydroxyalkyl group having 2 to 20 carbon atoms; on the proviso that if R.sub.1 is a hydrogen atom, neither R.sub.2 nor R.sub.3 is a hydrogen atom and at least one of R.sub.2 and R.sub.3 denotes the aforesaid phosphorylcholine derivative group, and that if R.sub.2 is a hydrogen atom, neither R.sub.1 nor R.sub.3 is a hydrogen atom and at least one of R.sub.1 and R.sub.3 denotes the aforesaid phosphorycholine derivative group. A polymer and a water-containing contact lens are obtained by polymerizing a starting component material including the above-mentioned diester monomer of the formula (I). A contact lens processing solution includes the polymer and a solvent for dissolving the polymer.

Diester monomer, its polymer, water-containing soft contact lens, and

Growing community of inventors

Matsudo, Japan

Nobuo Nakabayashi