Snow Brand Milk Products Co., Ltd.

Nobuo Miyata

Makoto Yoshihama

Masamichi Nakakoshi

Koji Tamura

Shoji Nakayama

Kenichi Kimura

Kohji Tamura

Novel 7.beta.-hydroxy-4-pregnene-3,20-dione derivatives are disclosed. The group of these compounds has possibility of being utilized as an intermediate for the synthesis of progesterone derivatives having ovulation-inhibiting activity. These compounds themselves have also cell differentiation activity for M1 cells.

Method for preparing 7.beta.-hydroxy-4-pregnene-3,20-dione derivatives

Physiologically active material SN-198C producing bacteria are disclosed which belong to Streptomyces species and products which have the following structural formula: ##STR1##

Physiologically active SN-198C compounds

A process for the preparation in high yield of 14.alpha.-hydroxy-4-androstene-3,6,17-trione which has an aromatase inhibition activity and is useful as an antitumor agent, in which the 6.beta.-hydroxyl group of 6.beta., 14.alpha.-dihydroxy-4-androstene-3,17-dione is selectively oxidized with the aid of visible light energy.

Process for preparing 14-.alpha.-hydroxy-4-androstene-3,6,17-trione

Novel androst-4-ene-3,17-dione derivatives are disclosed. The group of these compounds has biological activities, in particular, the inhibiting activity on human placenta-derived estrogen-synthesizing enzyme. Therefore these compounds are expected to be utilized in the field of medical care, particularly as anticancer drugs.

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Utsunomiya, Japan

Nobuo Miyata