Nippon Chemical Industrial Co., Ltd.

Takeda Chemical Industries, Inc.

Jidosha Denki Kogyo K.k.

Ebara Infilco Kabushiki Kaisha

Metac Sangyo Co., Ltd.

Seicho Kogyo Co., Ltd.

Nobuo Matsumoto

Hiroshi Kawakabe

Yasuko Manabe

Yasuo Sato

Kazuo Kamei

Kazhide Kitamura

Yoshiaki Kakumoto

Takashi Iwaizumi

Jiro Yakuwa

Tsuyoshi Takahashi

Mamoru Kanegawa

An industrially advantageous process for producing 3-chloromethyl-3-cephem derivative crystals. The process for 3-chloromethyl-3-cephem derivative production comprises: a first step in which a thiazolineazetidinone derivative (1) is reacted with a sulfonyl halide (2) in the presence of an acid in a solvent to obtain an azetidinone derivative (3); a second step in which the azetidinone derivative (3) is reacted with a chlorinating agent in an organic solvent to obtain a chlorinated azetidinone derivative (4); and a third step in which the chlorinated azetidinone derivative (4) is reacted with an alcoholate (5) at a pH of 8 or lower in a solvent comprising an alcohol and an ether and a 3-chloromethyl-3-cephem derivative (6) is recovered in the form of crystals.

Process for producing 3-chloromethyl-3-cephem derivatives

A chlorinated azetidinone derivative expressed by Formula (1) and an alcoholate are allowed to react in a solvent containing at least one of alcohols and an ether at a pH of 8 or less. Thus a 3-chloromethyl-3-cephem derivative expressed by Formula (2) is prepared.  In the formulas, Rrepresents a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic residue, and Rand Reach represent a substituted or unsubstituted aromatic hydrocarbon group.

Process for preparing crystalline 3-chloromethyl-3-cephem derivatives

A liquid dispensing apparatus capable of providing a customer with a desired amount of liquid depending on data recorded in a memory card purchased in place of liquor in the unit of a bottle. The apparatus includes a flowmeter to generate a signal representing the amount of liquid supplied, a card read/write device in which a reloadable memory card is inserted, and a CPU connected to the card read/write device and flowmeter. The CPU receives data of the memory card read by the card read/write device to open a valve depending on the data to dispense a desired amount of liquid and receives a signal from the flowmeter to operate the amount of liquid dispensed and close the valve. The card read/write device also carries out write of new data based on the operation of the CPU.

Liquid dispensing apparatus

A wiper blade assembly includes a rubber blade, a vertebrae holding the rubber blade, a yoke for supporting the vertebrae and a connector having arms for engaging the vertebrae, the rubber blade and the yoke at a common point for connecting the assembly together. The arms have projecting portions secured in openings in the vertebra with each arm having an outwardly opening groove receiving an engaging portion of the yoke and inwardly directed serrations engaging opposite sides of the blade.

Wiper blade apparatus

Organic phosphates of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are respectively an alkyl group; R.sup.3 is a phenyl group which is substituted at least by a pyridazinyloxy or pyridazinylthio group in which the pyridazinyl group may be substituted; and X is an oxygen or sulfur atom, or a salt thereof, have marked insecticidal-acaricidal activity against plant pests and mites, household pests, with very low toxicity to warm-blooded animals and fish.

Pyridazinyloxy (or thio) phenyl phosphates

Water or waste water is purified by passing same through a packed layer of active carbon utilizing the absorbing activity of active carbon. An apparatus for practicing this method is disclosed.

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Tokyo, Japan

Nobuo Matsumoto