Ajinomoto Co., Ltd.

Nobuo Kondo

Toshihiro Hatanaka

Hiroyuki Matsueda

Yoko Kageyama

Koji Ohsumi

Katsumi Maezono

Takao Ikenoue

Yoko Masuzawa

Ryusuke Hirama

Seiji Niwa

Akiyo Yamazaki

Takashi Umemura

Akiko Onuki

Yukio Iino

Hideyuki Tanaka

Takashi Yamamoto

Fumio Ohta

Masaru Takayanagi

Wataru Miyanaga

Nozomu Ishida

Nobuyasu Suzuki

Eiji Nakanishi

Yukio Nihei

Hidehiro Ichinose

Noriko Yasa

The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R' represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R&#x2033; represent a hydrogen atom.

Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof

The invention provides a prophylactic and therapeutic agent of diabetes mellitus, including a combination of an inhibitor of renal glucose reabsorption and a hypoglycemic agent. In accordance with the invention, hyperglycemia after meals, between meals and during fasting can be ameliorated. More specifically, in accordance with the invention, a therapeutic effect of diabetes mellitus as never been obtained by the hypoglycemic agents of the related art can be achieved.

Prophylactic and therapeutic agent of diabetes mellitus

A pharmaceutical composition for preventing and/or treating diabetes, diabetic complication, hyperinsulinemia, disorders of glucose metabolism or obesity, comprising a combination of the following compound, analogues or pharmaceutically acceptable salts thereof with a hypoglycemic agent. 

Therapeutic agents for diabetes

The present invention provides pyrazole-O-glycoside derivatives represented by the following formulae, used as a diabetic medicine. 

Pyrazole derivatives and diabetic medicine containing them

An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.

Lactam compounds and pharmaceutical use thereof

The present invention provides novel benzene compounds presented by the following formulas, and analogs thereof, that exert an ACC activity-inhibiting effect that is effective in the treatment of obesity, hyperlipemia, fatty liver, hyperglycemia, impaired glucose tolerance, diabetes, diabetic complications (diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, and diabetic macroangiopathy, hypertension, arteriosclerosis), hypertension, and arteriosclerosis. 

Benzene compounds

The present invention provides pyrazole-O-glycoside derivatives represented by the following formulae, used as a diabetic medicine 

The present invention provides pyrazole-O-glycoside derivatives represented by the following formulae, used as a diabetic medicine.

The present invention relates to pyrazole derivatives represented by the following formulas and analogues thereof, which can be used for a therapeutic agent for diabetes.

Growing community of inventors

Kawasaki, Japan

Nobuo Kondo