Tdk Corporation

Sony Corporation

Seikagaku Corporation

Dainippon Ink and Chemicals, Incorporated

Tomy Kogyo Co., Ltd.

Oki Electric Industry Co., Ltd.

Fujirebio Inc.

Seikagaku Kogyo Kabushiki Kaisha

Tomy Company, Ltd.

Fujirebio Kabushiki Kaisha

Dainippon Ink

Nobuo Kobayashi

Tsuneo Koji

Hisatomo Kunii

Kensaku Abe

Daisuke Morita

Akihiko Hosoda

Mizuho Ishikawa

Hiroshi Ikawa

Kiyoshi Umehara

Masahiro Kitajima

Hidehiko Yamaguchi

Hisaomi Yamamoto

Takashi Fujita

Tomofumi Nishimura

Akira Kimura

Masahiro Shibata

Hideaki Okayama

Toshio Suzuki

Kenryo Namba

Akira Nishino

Haruhisa Ujita

Tooru Sasaki

Masaru Nanao

Teruo Kitamura

Mitsunao Homma

Hajime Matsumoto

Eiji Sato

Yasuo Sekine

Akihiro Sekine

Issei Asabayashi

Akiyoshi Kadoiri

Takashi Kaga

Yasuko Konagai

Kazuhisa Kito

Yukie Mori

Kiyoshi Nagai

Yukimasa Yamaguchi

Kouichi Minami

Kenji Tokushige

Kenji Yoshida

Hiroaki Fujimaki

Hirofumi Nishimoto

Noriaki Hirano

Hiroshi Taguchi

Tsutomu Imai

Ryuta Motani

Jun Kusunoki

Masaharu Dozen

Yoshihiro Sugimoto

Tetsuo Katayanagi

Hiroshi Sakai

Mizuho Kataoka

Kouich Minami

Akio Matoba

Ryoko Shibuya

Tsunehiko Nishimura

Hiroyoshi Sawama

Yuki Masuda

Shigehisa Ishihara

Katsunobu Sagawa

Hikaru Yoshioki

Naoko Tanabe

Azuma Kawazoe

Naoko Koji

The purpose of the present invention is to provide a pharmaceutical composition that is useful for the treatment of diseases that are caused by an increase in bone resorption and that does not cause serious side effects even when used in combination with another drug. The present invention relates to: an &#x3b1;-oxoacyl amino-caprolactam derivative that is represented by formula (I) (in the formula, X is &#x2014;O&#x2014; or &#x2014;N(R)&#x2014; and Rrepresents an alkoxycarbonyl group having 1-10 carbon atoms); and a bone resorption inhibitor containing the &#x3b1;-oxoacyl amino-caprolactam derivative.

Alpha-oxoacyl amino-caprolactam derivative

The purpose of the present invention is to provide a pharmaceutical composition that is useful for the treatment of diseases that are caused by an increase in bone resorption and that does not cause serious side effects even when used in combination with another drug. The present invention relates to: an &#x3b1;-oxoacyl amino-caprolactam that is represented by formula (I) (in formula (I), X represents N or CH, Y represents O or CH, and Z represents S or CH); and a bone resorption inhibitor containing the &#x3b1;-oxoacyl amino-caprolactam.

&#x3b1;-oxoacyl amino-caprolactam

The purpose of the present invention is to provide a pharmaceutical composition that is useful for the treatment of diseases that are caused by an increase in bone resorption and that does not cause serious side effects even when used in combination with another drug. The present invention relates to: an &#x3b1;-oxoacyl aminocaprolactam derivative that is represented by formula (I) (in the formula, X is &#x2014;O&#x2014; or &#x2014;N(R)&#x2014; and Rrepresents an alkoxycarbonyl group having 1-10 carbon atoms); and a bone resorption inhibitor containing the &#x3b1;-oxoacyl aminocaprolactam derivative.

&#x3b1;-oxoacyl amino-caprolactam derivative

A resin is provided so as to cover four side faces of a piezoelectric multilayer body integrally and thus is effectively prevented from peeling from the piezoelectric multilayer body, whereby high adhesion is attained between the piezoelectric multilayer body and the resin. At the same time, the resin covers dicing surfaces in the side faces of the piezoelectric multilayer body, thereby effectively restraining the piezoelectric body and the electrodes from producing particles.

Piezoelectric device and method for manufacturing same

A piezoelectric element is provided with an element body, which has a pair of principal faces opposed to each other and an end face extending in a direction in which the pair of principal faces are opposed to each other, so as to connect the pair of principal faces, and which is comprised of a piezoelectric ceramic material; a pair of electrodes arranged respectively on the pair of principal faces; and a resin covering an entire area of the end face and arranged so as to make contact with the pair of electrodes. The resin has two edges in the aforementioned direction projecting outward in the aforementioned direction from the respective electrodes.

Piezoelectric element and method for manufacturing piezoelectric element

Novel cycloalkane carboxamide derivatives having an action that selectively inhibits cathepsin K, and a production process thereof, are provided, wherein (wherein Rand Rrepresent (substituted) alkyl groups, (substituted) alkenyl groups, (substituted) alkynyl groups, (substituted) aromatic hydrocarbon groups or (substituted) heterocyclic groups, ring A represents an alkylidene group having 5 to 7 carbon atoms, and ring B represents a formyl group or a hydroxymethyl group).

Cycloalkane carboxamide derivatives and production process of same

Cycloalkylcarbonylamino acid ester derivatives, which are raw material intermediates for a novel cycloalkane carboxamide derivative having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkylcarbonylamino acid ester derivative represented by formula (I), or a pharmaceutically acceptable salt thereof: (wherein, Rand Rrepresent alkyl groups, alkenyl groups, alkynyl groups, aromatic hydrocarbon groups, heterocyclic groups, etc., Rrepresents an alkyl group having 1 to 6 carbon atoms, and ring A represents a cyclic alkylidene group having 5, 6 or 7 carbon atoms).

Cycloalkylcarbonylamino acid ester derivative and process for producing the same

Novel raw material compounds are provided that are useful for producing novel cycloalkane carboxamide derivatives having cathepsin K inhibitory action. An oxazolone derivative represented by formula (I): [wherein, Rrepresents a substituted or unsubstituted alkyl group, substituted or unsubstituted alkenyl group, substituted or unsubstituted alkynyl group, substituted phenyl group, substituted or unsubstituted naphthyl group or substituted or unsubstituted heterocyclic group, and ring A represents a saturated cyclic alkylidene group having 6 to 7 carbon atoms].

Oxazolone derivative compounds having a 3-oxa-1-azaspiro[4.5] core

Cycloalkylcarbonylamino acid derivatives, which are raw material intermediates of a novel cycloalkane carboxamide derivative that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkylcarbonylamino acid derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof: (wherein, Rand Rrepresent alkyl groups, alkenyl groups, alkynyl groups, aromatic hydrocarbon groups, heterocyclic groups or the like, and ring A represents a cyclic alkylidene group having 5, 6 or 7 carbon atoms).

Cycloalkylcarbonylamino acid derivative and process for producing the same

The present invention is to provide manufacturing intermediates which can be led to useful &#x3b1;-ketoamide compounds having protease-inhibiting activity extremely economically and stereoselectively, and to provide epoxycarboxamide compounds, azide compounds and amino alcohol compounds represented by the following formulae: 

Epoxycarboxamide compound, azide compound, and amino alcohol compound, and process for preparing &#x3b1;-keto amide compound using them

A toy top playing apparatus for one person to play a toy top spinning game. A main body of the apparatus is provided with a display portion for displaying a game point, a play stage for spinning a toy top thereon, a dummy toy top simulating a toy top and arranged on the play stage, a sensor for detecting contact between the toy top and the dummy toy top, and a control section for processing the game point displayed on the display portion when the sensor detects the contact. The dummy toy top rotates on its axis, and a rotational direction thereof is controlled.

Toy top playing apparatus

An electric deviceis an organic positive thermistor in which, between two plate electrodesandconstituting an electrode couple, a conductive memberis disposed in a state being in a close contact with the plate electrodesand. The conductive memberis formed of many piled up resin particles each having its surface formed with a conductive layer of a residual material (fullerene residual), which is the soot including fullerenes generated via, for example, an arc discharging method, from which at least a part of fullerenes is removed. Such conductive layers are joined to each other to structure the conductive path and the conduction of the electric deviceis ensured in a normal state. When an inrush current flows, the conductive path is readily shut off by a small inflation of the resin particles due to the temperature rise.

Conductive member and manufacturing method thereof, and electric device and manufacturing method thereof

A transmitter for modulating an externally supplied audio signal according to a predetermined modulation system and for transmitting an obtained modulation signal includes a modulator for modulating the audio signal according to the modulation system; a balance convertor for converting the modulation signal in an unbalanced mode generated by the modulator into a balanced mode; and an antenna having a predetermined length formed by a leakage transmission line, the antenna emitting the modulation signal converted into the balanced mode.

Transmitter

An organic FETcomprises a substrateon which a gate insulation filmand a reformed layerare formed in this order, and a source electrodeand a drain electrodeare further arranged thereon at a predetermined distance from each other, and furthermore, an organic semiconductor layeris formed on and between the electrodesand. The reformed layerfixed on the gate insulation filmand attached to the organic semiconductor layercontains a specific compound containing the CN group or is composed of only a specific compound containing the CN group.

Field-effect transistor

Epoxycarboxamide compound, azide compound, and amino alcohol compound, and process for preparing alpha-keto amide compound using them

Growing community of inventors

Tokyo, Japan

Nobuo Kobayashi