Taiho Pharmaceutical Company Limited

Nobuo Kasahara

Junji Yamamoto

Kazuo Ogawa

Ichiro Yamawaki

Masato Nanri

Manabu Kaneda

Takashi Arima

Makoto Kajitani

Mitsugi Yasumoto

Etsuo Hasegawa

Akihiro Kawaguchi

Takaji Honna

Katsuo Toide

Bicyclolactam compounds, use thereof and intermediates for preparing thereof

Bicycloloactam compounds, use thereof and intermediates for preparing thereof

A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and sedative effects ##STR1## A bicyclolactam derivative represented by the following formula (1) is also disclosed, and is useful as an effective component of an anxiolytic agent ##STR2##

Bicyclolactam compounds, use thereof and intermediates for preparing

A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and sedative effects ##STR1## A bicyclolactam derivative represented by the following formula (1) is also disclosed, and is useful as an effective component of an anxiolytic agent ##STR2## .

The present invention provides carbamoyl-2 -pyrrolidinone compounds useful as medicaments for improving cerebral functions and activating cerebral metabolism or protecting against anoxic brain damage.

Carbamoyl-2-pyrrolidinone compounds

Diazabicycloalkane derivative

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Tokushima, Japan

Nobuo Kasahara