Toray Industries, Inc.

Nec Electronics Corporation

Nobuo Ida

Reiji Nishio

Kozo Takayama

Mariko Morishita

Yoshitaka Aoki

Masakazu Koiwa

Ikuro Maruyama

Masanobu Naruto

Hiroshi Kataoka

Tetsunosuke Kunitomo

Sanae Masuko

Reiji Kasukawa

Katsuaki Kojima

Yoshinori Kakizawa

Nobutaka Ida

Yoichiro Koshi

Taisuke Hirano

Masayuki Miyata

Junji Michizoe

Rumi Hikiba

Yoshinobu Nakajima

Yu-ichiro Sato

An immunogenic composition includes as an effective ingredient an antigen-adjuvant microparticle complex containing an antigen encapsulated in an adjuvant microparticle composed of an amphiphilic polymer(s) whose hydrophobic segment is a poly(hydroxy acid), or a particle composed of the antigen-adjuvant microparticle complex associated together, can induce a high immune response against the antigen even with a small amount of the antigen and a small number of doses, so that the immunogenic composition is useful as a vaccine effective for therapy and prophylaxis of infectious diseases, cancer and the like.

Immunogenic composition

A method for nasal administration of a pharmaceutical composition comprising a hydrophilic bioactive substance and any one of (a) to (c): (a) a peptide having the amino acid sequence shown in SEQ ID NO:1; (b) a peptide having the same amino acid sequence as shown in SEQ ID NO:1 except that one or several amino acids are deleted, substituted and/or added, the peptide having nasal mucosal permeability; (c) a peptide having an amino acid sequence represented by the reverse sequence of (a) or (b), the peptide having nasal mucosal permeability, with the proviso that a C-terminal amidated peptide is excluded. A hydrophilic bioactive substance having a low transmucosal absorption capability which has conventionally been able to be administered by only injection can be nasally administered. Such a pharmaceutical composition is useful for improvement of the pain and the inconvenience of patients caused by administration by injection.

Pharmaceutical composition for transnasal administration of peptide hormones or cytokines

A cell-penetrating peptide of (A) to (D) below gives cell membrane permeability and transmucosal absorbability to a physiologically active substance:

Cell-penetrating peptides

A microparticle includes an agglomerate of a hydrophilic active substance containing particle, which particle includes an amphiphilic polymer composed of a hydrophobic segment of poly(hydroxy acid) and a hydrophilic segment of polysaccharides or polyethylene glycol, and a hydrophilic active substance. It is characterized by an efficient inclusion of the hydrophilic active substance, and a release of the hydrophilic active substance at an appropriate speed in the human body, and is hence very useful as a DDS pharmaceutical preparation.

Microparticle and pharmaceutical composition thereof

An adsorbent of high-mobility-group proteins (HMG protein) which can remove HMG protein in body fluid is disclosed. The adsorbent according to the present invention has a water-insoluble carrier on which (a) substance(s) having (a) hydrogen-bondable functional group(s) and/or (a) hydrophobic functional group(s) is(are) immobilized.

Adsorbent of high-mobility-group protein and body fluid-purification column

A user circuit unit is configured by a gate array, a PLL circuit is configured in a microprocessor macro unit, a clock frequency output from the PLL circuit in the microprocessor macro unit is directly distributed to a user circuit unit (CLK), and the clock frequency distributed to the user circuit unit is distributed to the microprocessor macro unit through a frequency divider configured by the user circuit unit.

Clock distribution circuit

Drug for prevention and therapy of diseases caused by fibrinoid

Column for removing .beta..sub.2 -microglobulin

Growing community of inventors

Kamakura, Japan

Nobuo Ida