Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kirin Co., Limited

Other

Kyowa Hakko Kogyo Kabushiki Kaisha

Nobuo Hanai

Kazuyasu Nakamura

Motoo Yamasaki

Emi Hosaka

Yutaka Kanda

Kenya Shitara

Kazuhisa Uchida

Toyohide Shinkawa

Naoko Yamane

Akiko Furuya

Hideharu Anazawa

Mitsuo Satoh

Kazuya Yamano

Mamoru Hasegawa

Yoshihisa Kuwana

Susumu Imabeppu

Masamichi Koike

Hiromasa Miyaji

Kenji Shibata

Katsutoshi Sasaki

Tatsunari Nishi

Hajime Yoshida

Rinpei Niwa

Mikito Ito

Akihiro Iida

Mikiko Sakurada

Kazumi Miura

Masabumi Shibuya

Yoko Kawada

Kiyoshi Takatsu

Emi Shoji

Akira Tanaka

Hiromitsu Saito

Susumu Sekine

Toshiyuki Suzawa

Satoru Nagamura

So Ohta

Etsuyo Watanabe

Takeshi Takahashi

Masami Okabe

Yuji Ohki

Takashi Kuwabara

Satoshi Kobayashi

Maiko Hirota

Naoki Shimada

Rinpel Niwa

Osamu Mikuni

Kaoru Miyamoto

Kyosuke Nagata

Akira Kusano

Noboru Taniguchi

Tadachika Ozawa

Shozo Baba

Toshiaki Takezawa

Toshiaki Kamei

Toshiaki Saeki

Kazuhisa c/o Head Office Kyowa Kogyo Co Ltd Uchida

Emi c/o Biofrontier Laboratories Kyowa Hakko Kogyo Co Ltd Hosaka

Toyohide c/o Bio Process Research And Development Lab Shinkawa

The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

Antibody composition-producing cell

The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.

Method of modulating the activity of functional immune molecules

The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependant cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.

Method for producing recombinant antibody and antibody fragment thereof

The present invention relates to a cell and mammal in which GDP-mannose 4,6-dehydratase is knocked-out. The cell and mammal are useful for the production of an antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, such as an antibody useful for treating various diseases. The cell and mammal are also useful for the production of a fragment of the antibody, and a fusion protein having the Fc region of the antibody.

Cells with altered fucosylation and producing antibodies therefrom

Method for treating the Th2-mediated disease

Glycoengineered, recombinant antibody

The present invention relates to a cell for the production of an antibody molecule such as an antibody binding to ganglioside GM2, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

Antibody composition exhibiting cellular cytotoxicity due to glycosylation and containing ganglioside GM2 binding antibody

The present invention relates to a cell for the production of an anti-IL-5 antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

Anti-il-5 antibody composition exhibiting cellular cytotoxicity due to glycosylation

Antibody composition-producing cell with inactivated A-1,6-fusocyltransferase

Glycoengineered, recombinant antibody to CCR-4 with reduced fucosylation

The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, wherein the expression of GDP-mannose 4,6-dehydrogenase is inhibited by RNA interference.

Antibody composition-producing cell in which enzyme expression is inhibited by RNAi

Growing community of inventors

Machida, Japan

Nobuo Hanai