Takeda Pharmaceutical Company Limited

Takeda Chemical Industries, Inc.

Nobuo Cho

Nobuhiro Suzuki

Takashi Imada

Takenori Hitaka

Kazuhiro Miwa

Masami Kusaka

Koji Ono

Masahiro Ito

Toshio Tanaka

Hidekazu Tokuhara

Hiroshi Banno

Yasuyoshi Arikawa

Takaharu Hirayama

Hironobu Maezaki

Yasuhiro Imaeda

Yasuhiro Hirata

Nobuki Sakauchi

Moriteru Asano

Douglas Robert Cary

Ryo Mizojiri

Akinori Toita

Hironori Kokubo

Jun Fujimoto

Nao Morishita

Satoshi Sasaki

Naoyuki Kanzaki

Shizuo Kasai

Kazuyoshi Aso

Satoshi Endo

Masahiro Kamaura

Masami Kusuka

Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I):

Nitrogen containing heterocycles as CDK12 inhibitors

Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Heterocyclic compound

The present invention provides a compound represented by the formula: wherein Ris a Calkyl; Ris (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a substituent selected from the group consisting of (1') a halogen, (2&#x2032;) a hydroxy group, (3&#x2032;) a Calkyl and (4&#x2032;) a Calkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1&#x2032;) a halogen, (2&#x2032;) a Calkoxy-Calkyl, (3&#x2032;) a mono-Calkyl-carbamoyl-Calkyl, (4&#x2032;) a Calkoxy and (5&#x2032;) a mono-Calkylcarbamoyl-Calkoxy, or the like; Ris a Calkyl; Ris a Calkoxy, or the like; n is an integer of 1 to 4; or a salt thereof, as a thienopyrimidine compound having gonadotropin-releasing hormone antagonistic activity.

Thienopyrimidine compounds and use thereof

The present invention relates to a compound represented by wherein each symbol is as defined in the specification, a salt thereof and the like.

Substituted thieno[2,3-d]pyrimidin-2,4-dione compounds and uses thereof

The present invention provides a compound having melanocortin receptor agonist activity or antagonist activity, which is a novel biaryl compound represented by the formula (I): 

Biaryl compound and use thereof

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Osaka, Japan

Nobuo Cho