Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Nobukiyo Konishi

Masaaki Matsuo

Kiyoshi Tsuji

Shinji Shigenaga

Takashi Manabe

Ikuo Ueda

Hiroshi Matsuda

Hiroshi Miyake

Katsuya Nakamura

Daijiro Hagiwara

Kazuhiko Take

Tadashi Terasaka

Kenji Murano

Youichi Shiokawa

Masayuki Kato

Atsushi Akahane

Takashi Ogino

Yoshihiko Kitaura

Hidenori Azami

Yoshiteru Eikyu

Junya Ishida

Kazuo Nakai

Satoshi Aoki

Takeshi Kato

Natsuko Kayakiri

Masataka Morita

Norio Hashimoto

Hiroyuki Okumura

Hiroki Omori

Norihiro Igari

Hiroshi Sasaki

Toshiya Nakagawa

Ariyoshi Kubota

Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein Ris optionally substituted aryl or optionally substituted heteroaryl, Ris lower alkyl; Ris hydroxy or protected hydroxy; X is O or S; and -A- is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective 

Imidazole 4-carboxamide compounds with adenosine deaminase inhibiting activity

This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Piperazine derivatives

A compound of the formula (I):wherein Ris lower alkyl which is optionally substituted with

Triazole derivatives

This invention relates to piperazine derivatives of the formula:wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists

Piperazine derivatives as tachykinin antagonists

A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl;

A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl; Y is a direct bond or lower alkylene; and R.sub.1, R.sub.2, R.sub.3, R.sub.4 are as defined herein. The compounds are advantageously used as Tachykinin antagonists in the treatment of respiratory diseases, ophthalmic diseases and inflammatory diseases, for example.

The present invention relates to new pyrazole derivatives represented by the following general formula (I) ##STR1## wherein R.sup.1 is aryl which is substituted with substituent(s) selected from the group consisting of lower alkylthio, cyclo(lower)alkyl, hydroxy, hydroxy(lower) alkyl, cyano, lower alkylenedioxy, acyl, acyloxy, aryloxy and lower alkoxy optionally substituted with acyl or lower alkoxy,

Pyrazole derivatives, processes for preparation thereof and

This invention relates to new thiophene derivatives having antiinflammatory and analgesic activities and represented by the general formula [I]: ##STR1## wherein R.sup.1 is hydrogen, halogen, cyano, substituted lower alkyl, substituted or unsubstituted lower alkenyl, acyl, nitro, substituted or unsubstituted amino, sulfo, substituted or unsubstituted sulfamoyl, N-containing heterocyclicsulfonyl, hydoxy, substituted or unsubstituted heterocyclic group,

Thiophene derivatives

The present invention relates to new pyrazole derivatives represented by the following general formula (I) ##STR1## wherein R.sup.1 is aryl which is substituted with substituent(s) selected from the group consisting of lower alkylthio, cyclo(lower)alkyl, hydroxy, hydroxy(lower)alkyl, cyano, lower alkylenedioxy, acyl, acyloxy, aryloxy and lower alkoxy optionally substituted with acyl or lower alkoxy, R.sup.2 is halogen, halo(lower)alkyl, cyano or acyl, and R.sup.3 is aryl substituted with nitro, hydroxy, lower alkoxy, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl, provided that when R.sup.3 is aryl substituted with nitro, hydroxy or lower alkoxy, then R.sup.1 is aryl substituted with lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl, and pharmaceutically acceptable salts thereof.

The present invention concerns pyrazole derivatives of formula: ##STR1## used for the treatment of inflammation, pain, thrombosis and rheumatism.

Pyrazole derivatives, and pharmaceutical composition comprising the same

This invention relates to new alkanesulfonanilide derivatives and pharmaceutically acceptable salts thereof which have inflammatory activities and analgesic activities, to pharmaceutical compositions containing the same and to a method for the treatment of inflammatory disease or pains in human beings and animals.

New alkanesulfonanilide derivatives, processes for preparation thereof

This invention relates to new alkane-sulfonanilide derivatives of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.8 are each hydrogen, cyano, halogen, lower alkyl, halo (lower) alkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl or lower alkoxy,

Alkanesulfonanilide derivatives, processes for preparation thereof and

A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl,

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Nagaokakyo, Japan

Nobukiyo Konishi