Dainippon Sumitomo Pharma Co., Ltd.

Sumitomo Dainippon Pharma Co., Ltd.

Nobuhisa Fukuda

Yohei Ikuma

Hiroyuki Nakahira

Hidenori Kimura

Katsunori Tsuboi

Yoshihiro Horiuchi

Fumio Samizo

Satoshi Suetsugu

Yoshio Nakai

Atsushi Makita

Kozo Yoshida

Junya Ikeda

Takashi Takada

Kiyoto Sawamura

Masato Iwata

Kuniko Suzuki

Akira Fusano

A compound represented by formula (1) (in the formula: ring-D represents a three- to eight-membered hydrocarbon ring; Rrepresents an optionally substituted amino Calkyl group or the like; Rand Reach independently represent a hydrogen atom, a halogen atom, or the like; Rrepresents an optionally substituted Caryl group or the like; Rrepresents a hydrogen atom or the like; and ring-Q represents a (hetero)aryl group or the like which may be substituted with a carboxyl group or the like) or a pharmaceutically acceptable salt thereof exhibits an excellent FXIa inhibitory activity, and is useful as a therapeutic agent against thrombosis or the like. 

1-(cycloalkyl-carbonyl)proline derivative

The present invention provides a compound of formula (I): wherein Ris optionally substituted Calkyl, etc.; Ris hydrogen atom, etc.; G, G, Gand Gare (i), etc. ((i) Gis &#x2014;N(R)&#x2014;, Gis &#x2014;CO&#x2014;, Gis &#x2014;C(R)(R)&#x2014;, and Gis oxygen, etc.); Ris optionally substituted Calkyl, etc.; Rand Rare each independently optionally substituted Calkyl, etc.; Ris optionally substituted Calkyl, etc.; R, R, Rand Rare each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; Ris Calkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.

N-substituted-cyclic amino derivative

The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein Ris halogen, etc.; Ris H, etc.; Gis &#x2014;N(R)&#x2014;, etc.; Gis &#x2014;CO&#x2014;, etc.; Gis &#x2014;C(R)(R)&#x2014;, etc.; Gis oxygen, etc.; Ris optionally substituted Calkyl, etc.; Rand Rare independently the same or different, H, etc.; Ris H, optionally substituted Calkyl, etc.; R, R, Rc and Rare independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.]

Bicyclic heterocyclic derivative

A medicine which contains as an active ingredient a benzothiazin-3-one-compound represented by the formula (1): (wherein n is 3 or 4; R represents ethyl or hydrogen; and Rrepresents hologeno, alkoxy, haloalkyl, or haloalkoxy) or a pharmaceutically acceptable salt thereof. It is useful as a therapeutic or preventive agent for arthrosis deformans, chondrodegenerative discases such as chronic articular rheumatism, cancers, gingivitis, etc. Also provided are an intermediate for the compound and a process for producing the compound.

Benzothiazin-3-one compound and intermediate therefor

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Osaka, Japan

Nobuhisa Fukuda