Otsuka Pharmaceutical Company, Limited

Nobuhisa Fujita

Naoto Utsumi

Koichi Shinhama

Hidetsugu Tsubouchi

Satoshi Hayakawa

Shinichi Taira

Yoshikazu Haraguchi

Yoshihisa Tanada

Kimiyoshi Annaka

Takuya Furuta

Akihiro Yamamoto

Shinji Aki

Hisayuki Tsujimori

Koichi Tsuji

Yasuaki Muguruma

Shin Ogasawara

Yoshihiko Okaichi

Nobuhito Tada

Daisuke Nomi

Taizo Yamaguchi

An object of the present invention is to provide a method for producing an oxazole compound in a high yield. The object can be achieved by a compound represented by Formula (11): 

Synthetic intermediate of oxazole compound and method for producing the same

The present invention provides a novel intermediate for manufacturing a 2,3-dihydroimidazo[2,1-b]oxazole compound with a high yield and a high purity, and a manufacturing method of the intermediate. The present invention provides an epoxy compound represented by the general formula (2): wherein, R1 represents a hydrogen or a lower alkyl group; and R2 represents a piperidyl group represented by the general formula (A1): (wherein, R3 represents a phenoxy group having a halogen-substituted lower alkoxy group substituted on a phenyl group, and the like) and the like; and n represents an integer of 1 to 6, a manufacturing method of the epoxy compound, and a manufacturing method of an oxazole compound using the epoxy method.

Epoxy compound and method for manufacturing the same

The present invention provides a novel intermediate for manufacturing a 2,3-dihydroimidazo[2,1-b]oxazole compound with a high yield and a high purity, and a manufacturing method of the intermediate. The present invention provides an epoxy compound represented by the general formula (2): wherein, R1 represents hydrogen or a lower alkyl group; and R2 represents a piperidyl group represented by the general formula (A1): (wherein, R3 represents a phenoxy group having a halogen-substituted lower alkoxy group substituted on a phenyl group, and the like) and the like; and n represents an integer of 1 to 6, a manufacturing method of the epoxy compound, and a manufacturing method of an oxazole compound using the epoxy compound. 

The present invention provides a process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof, the process comprising reacting 1-cyano-3-octylguanidine or a salt thereof, with 3,4-dichlorobenzylamine or a salt thereof, in an ester-based organic solvent. According to the present invention, the reaction can be carried out at a low temperature using general-purpose equipment, and 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof can be produced in a high yield by a safe and easy process.

Process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof

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Osaka, Japan

Nobuhisa Fujita