Kyowa Hakko Kirin Co., Limited

Nobuhiro Yagi

Yasuki Kato

Hiroko Kusano

Masashi Nakakura

Masahiro Yamauchi

Atsushi Ishihara

Junichi Enokizono

Hiroko Sugishita

Takuya Tokuda

Tsuneaki Tottori

An object of the present invention is to provide a method of easily producing fine particles comprising a lipid, a fatty acid, or a derivative thereof, surface-modified with a water-soluble substance, etc. There are provided a method of producing a fine particles, surface-modified with a water-soluble substance, which contains the process of dispersing fine particles comprising a lipid, a fatty acid, or a derivative thereof, and dissolving or dispersing a surface modifier which is a lipid derivative, a fatty acid derivative, or an aliphatic hydrocarbon derivative of a water-soluble substance, in a liquid containing a polar organic solvent, and the like.

Method of producing fine particles surface-modified with water-soluble substance

An object of the present invention is to provide a composition for suppressing expression of a target gene, and the like. A composition comprising an RNA-encapsulated liposome, wherein the RNA contains a sequence consisting of 15 to 30 contiguous bases of a target gene mRNA (hereinafter, sequence X) and a base sequence (hereinafter, complementary sequence X') complementary to the sequence X, 1 to 90% of all sugars binding to the bases of the sequence X and the complementary sequence X&#x2032; being ribose substituted by a modifying group at 2&#x2032; position, and the lipid particle being capable of reaching a tissue or an organ containing an expression site of the target gene is provide.

Composition for suppressing expression of target gene

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Sunto-gun, Japan

Nobuhiro Yagi