Sapporo Breweries Limited

Daicel Chemical Industries, Ltd.

Other

Sapparo Breweries Limited

Etsuo Ito

Nobuhiro Watanabe

Suguru Takeo

Hisao Kado

Yutaka Mitani

Kiichi Uchida

Yoshitada Mori

Yasuo Yoneta

Naoki Abe

Minoru Kamimura

Yasukazu Nakakita

Hisao Yamamoto

Hideaki Uchida

Ryoichi Sato

Nobuyasu Enoki

A polysaccharide RON substance which has antitumor activity can be produced by fermenting sucrose with a synthetase. The synthetase can be isolated from Leuconostoc strains. Preferred strains of the microorganism are Leuconostoc mesenteroides FERM BP-2242, 2711, 2712, 2713, 2714, and 2670. The substance exhibits antitumor activity against syngenic tumor Meth A, a transplantable tumor in mice.

Process for producing polysaccharide ron substance with a synthetase

A biologically active polysaccharide RON substance which is excellent in such biological activities as antitumor activities, is produced by using a microorganism belonging to the genus Leuconostoc, which has an activity of producing the RON substance.

Method for producing biologically active polysaccharide RON substance

Disclosed are novel HP530 compounds, their derivatives or their pharmaceutically permissible salts, a process for preparing them and an antitumor substances containing them as active ingredient. The HP530 compounds and their derivatives expressed by the general formula below can be prepared by cultivating Streptomyces sp. HP530 (FERM BP-2786) or and chemically derivation. ##STR1## where X is a C.sub.2 -C.sub.4 acyl group or a hydrogen atom, Y is a C.sub.2 -C.sub.4 acyl group or a hydrogen atom and Z is a group expressed by the formula (II), (III) or (IV). ##STR2##

HP530 compounds and process for preparing the same

A polysaccharide RDP substance having the ultraviolet absorption spectrum depicted in FIG. 1, the infrared absorption spectrum depicted in FIG. 2 and the .sup.13 C-NMR spectrum depicted in FIG. 3 is obtained from rice bran by extraction.

Polysaccharide RDP substance

A polysaccharide RON substance having the ultraviolet absorption spectrum depicted in FIG. 1, the infrared absorption spectrum depicted in FIG. 2 and the .sup.13 C-NMR spectrum depicted in FIG. 3 is obtained from rice bran by extraction and purification; and pharmacological composition containing said RON substance.

Polysaccharide RON substance

Growing community of inventors

Yaizu, Japan

Nobuhiro Watanabe