Nippon Soda Co., Ltd.

Nobuhiro Umeda

Nobuo Mochizuki

Seiichi Uchida

Tomio Yagihara

Yasuyuki Shiinoki

Hirokazu Yamada

Katsunori Mikuma

Hiromi Horikoshi

Seiichi Ikeyama

Shiro Tsubokura

Isami Hamamoto

Nobuo Matsui

Seiji Tazaki

Tadayuki Nishibe

Mitsumasa Takada

Yukihiro Kanaguchi

Fumie Shirato

Takayoshi Sasaki

Hiroko Momoe

Shuichi Souma

Kunihito Ito

The present invention relates to a compound represented by formula (1): (wherein, R1, R2, R3 and R4 respectively and independently represent a hydrogen atom or a Calkyl group, and n represents an integer of 1 or 2) and a production process thereof, as well as an antioxidant that contains the compound as its active ingredient, and a kidney disease treatment agent, cerebrovascular disorder treatment agent, retina oxidative disorder inhibitor and lipoxygenase inhibitor that contain the antioxidant.

Diamine derivative, production process therefor and antioxidant

The present invention is directed to compounds represented by the formula (1): B-D-Z (1), wherein B represent the following formula (B-1), (B-2) or (B-3);  

Phenylazole compounds production process and antioxidants

Thienopyrimidine compounds and salts thereof and process for the preparation of the same

Phenylazole compounds represented by general formula (1) or pharmaceutically acceptable salts thereof and drugs for hyperlipemia which contain these compounds as the active ingredient, wherein A represents imidazolyl, pyrazolyl, etc.; B represents (1 ) or (1 ) (wherein R and R represent each hydrogen, C alkyl, etc; and k is 0 or an integer of 1 to 15); Y represents O, S, a bond, etc.; and Z represents an optionally substituted and saturated or unsaturated heterocycle containing 1 to 4 N, O or S atoms. Among all, compounds wherein Z is substituted chroman-2-yl, 2,3-dihydrobenzofuran-2-yl, etc. have an effect of inhibiting the formation of lipid peroxides too.

Phenylazole compounds, process for producing the same and drugs for hyperlipemia

Optically active compound

Preventive agent for platelet aggregation

Aminoacetonitrile derivatives, where the 2-position of aminoacetonitrile is optionally substituted by alkylthio groups, arylthio groups and heterocyclicthio groups. The process for making such compounds comprises reacting hydrogen cyanide with the desired corresponding R-S-H and recovering the crystallized salt thereof. The aminoacetonitrile derivatives are useful as starting materials to produce pharmaceutical and agricultural intermediates such as benzomide derivatives with fungicidal and herbicidal activities.

Aminoacetonitrile derivatives

The present invention relates to a 2,3-diaminoacrylonitrile derivative or salts thereof, having the formula ##STR1## wherein R represents an alkyl group (which may be substituted by unsubstituted or substituted phenyl groups, halogen atoms, C.sub.1-6 alkoxycarbonyl groups, carboxy groups, C.sub.1-6 alkoxycarbonyl C.sub.1-6 alkylthio groups, hydroxy groups, mercapto groups, cycloalkyl groups or heterocyclic groups containing oxygen atoms); an alkenyl group; a cycloalkyl group; an aryl group (which may be substituted by halogen atoms, C.sub.1-6 alkyl groups, nitro-groups, unsubstituted or substituted phenyl or phenoxy groups or heterocyclic groups containing oxygen atoms or sulfur atoms). The 2,3-diaminoacrylonitrile derivative can be used as starting materials for the production of pharmaceutical and/or agricultural intermediates such as cyanoimidazoles, cyanopyrazines or other cyano-substituted heterocycles.

2,3-diaminoacrylonitrile derivatives and process for making the same

Growing community of inventors

Odawara, Japan

Nobuhiro Umeda