Chugai Seiyaku Kabushiki Kaisha

Basilea Pharmaceutica Ag

Hoffmann-la Roche Inc.

The University of Tokyo

Nobuhiro Oikawa

Nobuo Shimma

Eisaku Mizuguchi

Hiroshi Fukuda

Isao Umeda

Masahiro Sakaitani

Jun Ohwada

Tadakatsu Hayase

Masao Tsukazaki

Nobuya Ishii

Kenji Morikami

Hideo Ishitsuka

Kazuo Hattori

Yasunori Kohchi

Hitomi Suda

Tohru Ishikawa

Hiroshi Sakamoto

Takashi Emura

Yoshiyuki Ono

Hidenori Takahashi

Toshiyuki Tsukaguchi

Hatsuo Kawada

Toshiya Ito

Sawako Ozawa

Noriyuki Furuichi

Kazutomo Kinoshita

Yasuharu Kato

MinJeong Park

WooSang Hong

Kohsuke Asoh

Fumio Watanabe

Hirosato Ebiike

A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: 

Tetracyclic compound

The present invention provides a compound represented by the formula (1):  

Heteroarylphenylurea derivative

It is intended to provide a compound represented by the formula (1): [wherein Ar is an arylene group to be attached selected from the following formula (2): (wherein * represents a binding site to a nitrogen atom and ** represents a binding site to T); T represents &#x2014;(O)&#x2014;R; R represents a C-Calkyl group or the like; n represents 0 or 1; X represents O or the like; R, Rand Rare independently selected from a hydrogen atom or C-Calkyl; or Rand Rmay join together with an urea structure containing the nitrogen atoms to which they bind to form a 5- or 6-membered heterocycle; Y represents CH or N], or a pharmaceutically acceptable salt thereof or a prodrug thereof and a pharmaceutical composition containing the same.

Pyrazolopyridine and pyrrolopyridine multikinase inhibitors

N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.

N-substituted carbamoyloxyalkyl-azolium derivatives

N-substituted carbamoyloxyalkyl-azolium derivatives Which have antifungal activity and are useful for the treatment of fungal diseases.

N-phenyl substituted carbamoyloxyalkyl-azolium derivatives

Intermediates for N-substituted carbamoyloxyalkyl-azolium derivatives

Novel 5&prime;-deoxy-cytidine derivatives represented by the general formula (I)

5&prime;-deoxy-cytidine derivative administration to treat solid tumors

Novel 5'-deoxy-cytidine derivatives represented by the general formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom or a group easily hydrolyzable under physiological conditions; R.sup.2 is a hydrogen atom, or --CO--OR.sup.4 group [wherein R.sup.4 is a saturated or unsaturated, straight or branched hydrocarbon group consisting of one to fifteen carbon atoms, or a group of the formula --(CH.sub.2).sub.n --Y (in which Y is cyclohexyl or phenyl; n is an integer from 0 to 4)]; R.sup.3 is a hydrogen atom, bromo, iodo, cyano, a C.sub.1-4 alkyl group [which may be substituted with halogen atom(s)], a vinyl or ethynyl group [which may be substituted with halogen atom(s), C.sub.1-4 alkyl, cycloalkyl, aralkyl, or aromatic ring which may have one or more hetero atom(s)], or an aralkyl group which may be substituted for use in medical therapy, especially tumor therapy.

5'-deoxy-cytidine derivatives

Compounds of the formula (I) ##STR1## wherein R.sup.1 is each independently hydrogen or a group easily hydrolyzable under physiological conditions;

5'deoxycytidine derivatives

Growing community of inventors

Kawasaki, Japan

Nobuhiro Oikawa