Chugai Seiyaku Kabushiki Kaisha

Nobuhiro Oi

Minoru Shindo

Yusuke Harada

Isao Matsunaga

Haruki Ogawa

Hiroshi Okazaki

Teizo Shinozaki

Takao Noto

Bunya Aoki

Takao Kimura

Hisao Endo

Kanji Moro

Toshiyuki Nebashi

Sakae Takaku

Shigeyuki Kataoka

Kouji Furuno

Takeaki Hirano

Toshio Kuroki

Masahiko Matsumoto

Kana Kojima

.alpha.-Substituted ureido-benzylpenicillanic acids of the formula ##STR1## (wherein R.sup.1, X and Y are as defined in the description) and pharmaceutically acceptable salts thereof, and a bactericidal composition comprising the above penicillanic acid or the salt and a pharmaceutically acceptable carrier are disclosed. The acids and salts thereof have high antibacterial activities against Gram-positive and Gram-negative bacteria, particularly those of the genus Pseudomonas.

.alpha.-Substituted ureido-benzylpenicillanic acids

Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1 R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.

Cephalosporin derivatives

Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.

Penicillanic acid derivatives which have an excellent antibacterial action particularly against bacteria belonging to family Pseudomonas aeruginosa and are represented by the formula ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 and n are as defined above, and salts thereof; and a process for preparing the same are disclosed.

Penicillanic acid derivatives

A pharmaceutical composition for prevention and treatment of gastritis and peptic ulcer of mammals including human beings which contains a bis(benzamido)benzene derivative represented by the formula ##STR1## wherein X and Y are as defined hereinbelow, or an acid addition salt thereof, as an active ingredient, and a method of the use thereof are disclosed.

Pharmaceutical composition and method of the use thereof

Bis(benzamido)-benzene derivatives having various pharmaceutical activities such as activity for preventing and treating peptic ulcer, peripheral vasodilating action, hypotensive activity and analgesic activity and represented by the formula ##STR1## wherein X, Y, Z, R.sub.1, R.sub.2 and R.sub.3 are as defined hereinafter and a process for preparing the same are disclosed.

Bis(benzamido)-benzene derivatives

A pharmaceutical composition for prevention and treatment of gastritis and peptic ulcer of mammals including human beings which contains a bis(benzamido)-benzene derivative represented by the formula ##STR1## wherein X and Y are as defined hereinbelow or an acid addition salt thereof as an active ingredient, and a method of the use thereof are disclosed.

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Hoya, Japan

Nobuhiro Oi