Chugai Seiyaku Kabushiki Kaisha

Nobuhiro Ohi

Hiroshi Suzuki

Takashi Mori

Tatsuya Kato

Yasuhiro Yamashita

Hiroharu Matsuoka

Yoshiyuki Suzuki

Masahiko Mihara

Kenichi Akamatsu

Nobuaki Kato

Yoshiyuki Ohsugi

Yasuhisa Takeda

Michitaka Akima

Shin Shimaoka

Tomokazu Ozaki

Keiichiro Tsuji

Kazuhiko Tamura

Katushito Miyamoto

Hiromichi Nishina

The present invention is directed to a compound represented by formula (I): wherein, for example, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 each represents a hydrogen atom; R.sub.6 and R.sub.7 each represent a substituted or unsubstituted lower alkyl group; A represents a group represented by formula (II): ##STR1## wherein R.sub.5 represents, for example, a hydrogen atom; and n represents an integer of 2 to 6, or a stereoisomer or optical isomer thereof and a pharmaceutically acceptable salt thereof and compositions and methods for treating ischemic diseases. The compounds represented by formula (I) have an inhibitory action on calcium overload in addition to a vasorelaxing activity (calcium antagonism) and an inhibitory action on lipid peroxidation and are useful as a preventive or treating agent for ischemic diseases and hypertension.

Benzene derivatives, compositions and methods for treating ischemic

Methotrexate derivative

A compound of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group which may be substituted with hydroxy, lower alkyl or di-lower alkylamino; R.sub.2 is a hydrogen atom, an amino group or a lower alkylamino group; and R.sub.3 is a lower alkyl group, and a non-toxic salt thereof, and a process for preparing the same are disclosed. The compound and the salts thereof exhibit anti-allergic effects by the two different mechanisms and are expected to be useful as drugs for treating allergic diseases such as asthma, pollen allergy, atopic dermatitis and the like.

Pyridine derivatives and their use as anti-allergic agents

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Shizuoka, Japan

Nobuhiro Ohi