Riken Corporation

The Institute of Physical and Chemical Research

The General Hospital Corporation

Nobuhiro Morishima

Takehiko Shibata

Hikaru Mizumura

Keiko Nakanishi

Junying Yuan

The present invention provides the antibody that react with the cleavage product of vimentin, but not with intact vimentin.

Antibody against cleavage product of vimentin

This invention relates to nucleic acids encoding caspase-12, proteins encoded by casp-12 nucleic acids, vectors, and hosts transformed with vectors. Caspase-12 is a member of the caspase family, which also includes mammalian interleukin-1&bgr;-converting enzyme (ICE). Caspases are thought to carry out the execution phase of apoptosis in a cascade of proteolytic events. The invention also relates to the use of caspase-12 to induce programmed cell death.

Programmed cell death and caspase-12

The present invention relates to a site-specific endonuclease which recognizes a specific nucleotide sequence, to a gene coding for the endonuclease, to a recombinant vector containing the gene, to a transformant containing the vector, and to a process for producing the endonuclease.

Endonuclease

Antibody against cleavage product or vimentin

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Saitama, Japan

Nobuhiro Morishima