Kabushiki Kaisha Toshiba

Toshiba Medical Systems Corporation

Nobuhiro Gemma

Akira Miura

Syun Egusa

Kazushige Yamamoto

Kouichi Ichimura

Toshio Nakayama

Makoto Azuma

Katsuyuki Naito

Koichi Mizushima

Koji Hashimoto

Naoko Nakamura

Masayoshi Takahashi

Hiroyuki Hieda

Jun Okada

Keiko Ito

Kuniyoshi Tanaka

Keiichi Yamamoto

Shinya Aoki

Masaru Nikaido

Yasushi Mori

Sadato Hongo

Shun Egusa

Takashi Ishino

Tetsuya Kuwabara

Keijiro Hirahara

Akiyoshi Nakamura

Daiji Hirosawa

Madoka Takase

Akiko Shimojo

Hiroyuki Sasabe

Taiji Furuno

Takano Iwakiri

According to one embodiment, a multi-nucleic-acid amplification reaction tool includes a support and a plurality of types of primer sets. The support is configured to be able to support a reaction field of a liquid phase. A plurality of types of primer sets are fixed in a releasable state, for each type, on mutually independent fixing regions of at least a surface of the support, which is in contact with the reaction field, when the liquid phase forms the reaction field. A plurality of types of primer sets are configured to amplify the respectively corresponding target sequences.

Multi-nucleic-acid amplification reaction tool

One embodiment is related to a method of analyzing plural samples. The method includes amplifying a plurality of samples using a first primer and second primer, wherein the first primer includes a tag sequence having a sequence different from a sample to one another and wherein a second primer used in pair with the first primer in independent reaction systems for the respective samples to obtain an amplified product in which the tag sequence is introduced, mixing amplified products obtained in the plurality of reaction systems, making the mixed amplified product react with a nucleic acid probe immobilized on a substrate, and detecting the amount of hybridization that has occurred.

Sample analysis method and assay kit used therein

There is provided a nucleotide primer set for LAMP amplification, used for detecting genotypes of single-nucleotide polymorphisms G590A, G857A and T341C of a NAT2 gene. There is also provided a nucleotide probe for detection of an amplification product amplified with the primer set according to the present invention. There is also provided a method of detecting the genotypes of NAT2 gene single-nucleotide polymorphisms G590A, G857A and T341C by using the primer set according to the present invention.

Nucleotide primer set and nucleotide probe for detecting genotype of N-acetyltransferase-2 (NAT2)

A nucleic acid detection device includes a flow channel through which a solution containing a nucleic acid recognition body flows, probe electrodes having immobilized nucleic acid probes, and a counter electrode used to measure an electrochemical response of the nucleic acid recognition body. The flow channel includes a curved portion and a straight portion continued from and located downstream of the curved portion. The probe electrodes are arranged at intervals along the straight portion, avoiding an upstream end of the straight portion that is located within a distance L from the curved portion. The distance L is given by L=0.065&#xd7;Re&#xd7;D, Re=&#x3c1;uD/&#x3bc;, and D=4S/Lp where &#x3c1;, u, and &#x3bc; are a concentration, a flow velocity, and a viscosity of the solution, and S and Lp are a sectional area and a wall peripheral perimeter of the flow channel, respectively.

Nucleic acid detection device

There is provided is a nucleotide primer set for LAMP amplification used for detecting genotypes of single-nucleotide polymorphisms C677T and A1298C of an MTHFR gene. There is also provided a nucleotide probe for detecting an amplification product amplified by the primer set according to the present invention. There is also provided a method of detecting the genotypes of the single-nucleotide polymorphisms C677T and A1298C in the MTHFR gene, by using the primer set according to the present invention.

Nucleotide primer set and nucleotide probe for detecting genotype of methylene tetrahydrofolate reductase (MTHFR)

This invention is characterized in that information is recorded by injecting electric charge into a charge holding region made from a donor or acceptor, and the recorded information is reproduced by using changes in luminescence characteristics of the luminescent material contained in the charge holding region or a light emitting region formed near the charge holding region, that occur in accordance with the charge condition of the charge holding region.

Luminescent recording layer holding a plurality of positive or negative

A light-modulating element having a RQB medium, a pair of electrodes provided on the RQB medium and connected to a high-frequency power supply, a signal light source for emitting two signal light beams, and two optical fibers for guiding the signal light beams to the RQB medium. In the element, the conditions .sigma..sub.23 .ltoreq..sigma..sub.12 and .sigma..sub.23 .ltoreq..sigma..sub.13 are satisfied, where .sigma..sub.12 is the standard deviation (inhomogeneous broadening) of energies of impurities between a first level and a second level, .sigma..sub.13 is the standard deviation (inhomogeneous broadening) of energies of impurities between first level and a third level, and .sigma..sub.23 is the standard deviation (inhomogeneous broadening) of energies of impurities between the second and third levels, all impurities existing in the RQB medium.

Function element using quantum interference effect

Two mirrors comprising a resonator, arranged facing to each other interpose an EIT layer, which is a solid containing an impurity. A controlling light from a controlling light source and a pumping light from a pumping light source enter the EIT layer. A photodiode detects the intensity of an LWI laser light (a signal light outputted from the EIT layer) outputted from one of the mirrors. A filter for cutting the controlling light is provided between the photodiode and the mirror. Two kinds of lights, that is, the controlling light and the pumping light are used in all the .LAMBDA., V, .XI. type three levels. In the .LAMBDA. type three levels, the controlling light is used for supposedly exciting between the levels, and the pumping light is used for pumping electrons from the level to the level via the level. In the V type three levels, the controlling light is used for exciting between the levels, and the pumping light is used for pumping electrons from the level to the level via the level. In the .XI. type three levels, the controlling light is used for supposedly exciting between the levels, and the pumping light is used for pumping electrons from the level to the level via the level.

Optical device capable of functioning without a population inversion

A method of recording information in an optical recording medium, which comprises two steps. In the first step, a coherent light pulse train which resonates with a transition between the first and third energy levels and coherent light which resonates with a transition between the second and third energy levels or a transition between the first and second energy levels are applied to the optical recording medium, thereby causing the light pulse train to pass through the optical recording medium. In the second step, an intensity change of an external field is supplied to the medium, while the light pulse train is passing through the optical recording medium, thereby fixing sites in a thickness direction of the medium, at which the absorption spectrum of the medium is changed.

Optical recording medium, method of recording information, method of

An optical element and a method capable of electromagnetically inducing transparency in a solid. The optical element includes a solid having a number N of sites characterized by at least three energy levels including a first level higher than a second and a third lower than the second, and an excitation device configured to irradiate the solid with a first light having a wavelength corresponding to the energy difference between the first and the second level, and a second light having a wavelength corresponding to the energy difference between the first and the third level. The solid satisfies .sigma..sub.23 .ltoreq..sigma..sub.12 and .sigma..sub.23 .ltoreq..sigma..sub.13 where .sigma..sub.12, .sigma..sub.13 and .sigma..sub.23 are respectively the standard deviations of the energy differences between the first and second level, between the first and third level, and between the second and third level.

Optical element

There is provided an optical detection method comprising the steps of preparing a solid body having an energy level structure constituted by at least three energy levels, and irradiating first and second coherent light on the solid body to optically detect the physical structure of the solid body, wherein the detection step satisfies the following conditions:

Optical information reproduction by irradiating two laser beams into a

A method of manufacturing a solid-state material comprises a first step of preparing a starting material having an energy-level structure with at least first, second and third energy levels, each having a specific level width, the first energy level is the lowest of the three levels, one of the second and third energy levels changing the energy-level structure when light having a predetermined wavelength is applied to the material, and the energy-level structure remaining so changed even after the application of the light, and a second step of irradiating the starting material with a first coherent light beam resonating with transition between the first and third energy levels and a second coherent light beam resonating with transition between the second and third energy levels in a case that the third level is a level which changes the energy level structure, thereby changing a distribution of angular frequency in a plane one axis of which is a first transition angular frequency corresponding to the transition between the first and third energy levels and the other axis of which is a second transition angular frequency corresponding to the transition between the second and third energy levels, thereby to form a solid-state material having new distribution of transition angular frequency, wherein the second step includes a step of setting a spectral width of the first light beam, Rabi characteristic angular frequency for transition of the second light beam and Rabi characteristic angular frequency for transition of the second light beam within one of two inhomogeneous widths for the first and second transition angular frequencies which is broader than the other.

Solid-state material, method of manufacturing the solid-state material,

A recording medium includes an underlying conductor layer, an insulating layer formed on the underlying conductor layer, and a recording layer formed with a domain structure on the insulating layer, wherein the recording layer contains a domain constituent material and an impurity whose molar ratio to the domain constituent material is 10% or lower, and the highest occupied molecular orbital of the impurity is higher in energy than the highest occupied molecular orbital of the domain constituent element, or the lowest unoccupied molecular orbital of the impurity is lower in energy than the lowest unoccupied molecular orbital of the domain constituent material.

Recording medium and recording/reproduction method

A method of forming an organic thin film includes developing organic molecules having a hydrophilic portion and a hydrophobic portion on a water surface, and compressing the organic molecules thereby to form a monomolecular layer of a predetermined surface pressure. The monomolecular layer is brought into contact with a given substrate. Then, the substrate to which the monomolecular layer is adhered, is pulled at such a rate that the surface pressure is not substantially lowered, thus transferring the monomolecular layer onto the substrate.

Method of forming an organic thin film

An apparatus for detecting an electrostatic force in a solution includes a sample and a cantilever. An end of the cantilever is conductive and has voltage applied to it. The apparatus detects electrostatic interaction caused by functional groups of target molecules in the solution.

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Yokohama, Japan

Nobuhiro Gemma