Nippon Chemical Industrial Co., Ltd.

Nobuhiko Oohara

Kazuhiro Nakatsui

Keisuke Ohto

Yoshirou Kaneda

Hiroaki Kodama

Tsuneo Imamoto

Hiroaki Konishi

Chiaki Ono

Hikaru Abutani

The phosphine transition metal complex of the present invention is represented by formula (1). Preferably, Rand Rare identical groups, Rand Rare identical groups, Rand Rare identical groups, Rand Rare identical groups, Rand Rare identical groups, and n and y are identical numbers. The phosphine transition metal complex is suitably obtained by reacting a phosphine derivative represented by formula (2) and a phosphine derivative represented by formula (3) with a salt of a transition metal of gold, copper or silver. See the description for the meanings of the symbols in each formula.

Phosphine transition metal complex, method for producing same, and anticancer agent

The anti-cancer agent of the present invention contains at least one kind of phosphine transition metal complex selected from a group of compounds represented by the following Formulae (1a) to (1d). According to this anti-cancer agent, an anti-cancer agent is provided which has a higher anti-cancer activity and lower toxicity compared to anti-cancer agents in the related art. In Formulae (1a), (1b), (1c), and (1d), Rand Rrepresent a linear or branched alkyl group, and Rhas a higher priority than Ras ranked according to RS notation. Rand Rrepresent a hydrogen atom or a linear or branched alkyl group. M represents an atom of a transition metal selected from a group consisting of gold, copper, and silver. Xrepresents an anion. 

Anti-cancer agent

An anticancer agent having a novel chemical structure and high anticancer activity is provided. A phosphine transition metal complex of general formula (1) and an anticancer agent containing the complex are disclosed.  Rand R, which may be the same or different, each represent a group having 1 to 10 carbon atoms selected from a straight-chain or branched alkyl group, a cycloalkyl group, a substituted cycloalkyl group, an adamantyl group, a phenyl group, and a substituted phenyl group; Rand R, which may be the same or different, each represent a hydrogen atom, a straight-chain alkyl group having 1 to 6 carbon atoms or branched alkyl group having 1 to 6 carbon atoms; or Rand Rare taken together to form a saturated or unsaturated ring which may have a substituted group; M represents a transition metal atom selected from the group consisting of gold, copper, and silver; and Xrepresents an anion.

Phosphine transition metal complex, process for producing same, and anticancer agent

There is provided a novel transition metal phosphine complex having excellent anticancer activity. The transition metal phosphine complex is represented by general formula (1): (wherein Rs and Rs each represent an alkyl group, a cycloalkyl group, an aryl group, an aralkyl group, a pyridyl group, or a pyrimidyl group; Rs and Rs each represent an alkyl group or a cycloalkyl group, provided that each Rand each Rare not the same group and that each Rand each Rare not the same group; As each represent a linear alkylene group or a cis-vinylene group; M represents a gold atom, a silver atom, a copper atom, or a platinum atom; and B represents an anionic species).

Transition metal phosphine complex, method for producing same, and anticancer agent containing transition metal phospine complex

A phosphine transition metal complex is expressed by general formula (1): 

Phosphine transition metal complex, method for producing the same, and antitumor agent containing the same

The present invention provides a process for producing an optically active phosphorus heterocyclic dimer including reacting, in the presence of a base, primary phosphine represented by formula (1)R&#x2014;PH&#x2003;&#x2003;(1)is reacted with a compound represented by formula (2)Y&#x2014;CH&#x2003;&#x2003;(2)in the presence of a base; the product is reacted with boron trihydride, oxygen, or sulfur to obtain a phosphorus heterocyclic compound represented by formula (3): the resultant compound is dimerized to produce a phosphorus heterocyclic dimer represented by formula (4): and then oxygen, sulfur, or borane is removed from the resultant phosphorus heterocyclic dimer to obtain an optically active phosphorus heterocyclic dimer represented by formula (5): 

Process for producing optically active phosphorus heterocyclic dimer

An anti-cancer agent contains a phosphine transition metal complex having a ferrocene skeleton, the complex being represented by general formula (3) below: 

Growing community of inventors

Tokyo, Japan

Nobuhiko Oohara