Fuji Photo Film Company, Limited

Fujifilm Corporation

Aichi Prefecture

Nobuhiko Ogura

Hitoshi Shimizu

Katsuaki Muraishi

Yasunobu Sakaguchi

Nobufumi Mori

Yoshiyuki Kunuki

Masashi Hakamata

Katsumi Hayashi

Hisashi Ohtsuka

Tatsuo Fujikura

Masayasu Konishi

Koji Kuruma

Masayuki Naya

Keiko Neriishi

Shu Sato

Hideyuki Morimoto

Takashi Takahashi

Hiroyuki Ota

Tetsuya Mitsudomi

Yasushi Yatabe

Masato Some

Shuta Tomita

Yasunori Ohta

Takashi Kobayashi

Yuichi Hosoi

Tomoki Inoue

Hiromi Ishikawa

Toshihide Ezoe

Toshihito Kimura

Taizo Akimoto

Masahiro Ohnishi

Takashi Kubo

Seishi Ikami

Yasushi Kojima

Chiyuki Umemoto

Sumihiro Nishihata

Yukinori Nishioka

Hiromi Shibata

Masayoshi Yamamoto

Tohru Tsuchiya

Yoshihiko Hoda

A radiographic image reading device includes a reading unit configured to photoelectrically read photostimulated luminescence light produced from a storage phosphor sheet illuminated with excitation light, the storage phosphor sheet, at which a radiographic image is stored, being scanned by a scanning unit using the excitation light; and a control unit configured to control the reading unit so as to cause the reading unit, in a case of reading at a first resolution, to read with excitation light at a first scanning speed and a first intensity and, in a case of reading at a second resolution that is a higher resolution than the first resolution, to read with excitation light at a second scanning speed that is slower than the first scanning speed and a second intensity that is smaller than the first intensity.

Radiographic image reading device, computer readable medium, and radiographic image reading method

The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene in lung cancer tissues isolated from the patient.

Method of classifying gene expression strength in lung cancer tissues

The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene selected from the group consisting of in lung cancer tissues isolated from the patient.

A sensor unit of a surface plasmon resonance (SPR) assay system includes a transparent dielectric medium. A thin film has a first surface and a sensing surface. The first surface is connected with the dielectric medium to constitute an interface. The sensing surface is back to the first surface, for detecting (bio) chemical reaction. A flow cell block has a flow channel for flowing of the sample to the sensing surface. Attenuated total reflection of illuminating light is checked at the interface, to analyze interaction between ligand and analyte as samples. The flow channel includes a first inner surface, disposed opposite to the sensing surface to extend along, for passing the sample to flow between. The first inner surface has a height, defined with reference to the sensing surface, and in a range of 200-500 microns.

Sensor unit and assay method of assay in utilizing attenuated total reflection

A flow cell device is incorporated in the sensor unit for surface plasmon resonance (SPR) assay. A box shaped flow cell body has a lower surface, and is disposed in contact of the lower surface with a sensing surface for detecting reaction of sample. Two flow channels are formed in the flow cell body, for flow of the sample. Each of the flow channels include a fluid passageway, formed in the lower surface, for flow of the sample in contact with the sensing surface. Two end cavities are formed in an upper surface of the flow cell body and open therein, to extend from ends of the fluid passageway. The flow channels are arranged adjacent to one another, disposed to extend in a direction of the flow. Fluid passageways of the flow channels are overlapped partially on one another in a flow cell longitudinal direction of the flow cell body.

Flow cell device, sensor unit and assay apparatus

A sensor unit of a surface plasmon resonance (SPR) assay system includes a transparent dielectric medium. A thin film has a first surface and a sensing surface. The first surface is connected with the dielectric medium to constitute an interface. The sensing surface is back to the first surface, for detecting (bio)chemical reaction. A flow cell block has a flow channel for flowing of the sample to the sensing surface. Attenuated total reflection of illuminating light is checked at the interface, to analyze interaction between ligand and analyte as samples. The flow channel includes a first inner surface, disposed opposite to the sensing surface to extend along, for passing the sample to flow between. The first inner surface has a height, defined with reference to the sensing surface, and in a range of 200-500 microns.

A test piece for use in biological analysis of a sample is formed of a strip-like substrate and numbers of known specific binding agents which are different from each other and are arranged in a line at predetermined intervals in the longitudinal direction of the strip-like substrate.

Test piece, method of and apparatus for manufacturing the test piece and method of and system for reading the same

It is an object of the present invention to provide a method for simultaneously carrying out the detection or measurement of a substance interacting with a physiologically active substance immobilized on a biosensor and the analysis of the effects of the above substance on the biological activity of the physiologically active substance. The present invention provides a method using a biosensor formed by immobilizing a physiologically active substance on a substrate, wherein the detection and measurement of a substance interacting with said physiologically active substance and the measurement of the biological activity of said physiologically active substance are carried out on said single biosensor.

Measurement method using biosensor

An assay apparatus is loaded with a sensor unit as surface plasmon resonance (SPR) biosensor, which includes a transparent dielectric medium and thin film. A first surface of the thin film is a thin film/dielectric interface. Its sensing surface causes reaction of sample fluid. An optical assay unit assays reaction of the sample fluid by detecting illuminating light reflected by the interface. Measured data from the optical assay unit is compared with a reference parameter, to evaluate suitability of the measured data for analysis. If lack of the suitability is estimated in the evaluation, a succeeding density of the sample fluid to be used in a succeeding evaluating assay is determined according to the measured data with the estimated lack of the suitability. The sample fluid is prepared at the succeeding density by mixing with diluent fluid, and then is used for the succeeding evaluating assay.

Apparatus and method of assay in utilizing attenuated total reflection

A measuring apparatus and a measuring method are configured to measure a concentration of an organic solvent in a sample solution, measure a concentration of the organic solvent in a concentration control solution, calculate a mixture amount by which the concentration control solution is mixed into the sample solution of a preset amount so that the concentration of the organic solvent in the sample solution is equal to a preset concentration based on the two concentrations, mix the concentration control solution of the calculated mixture amount with the sample solution of the preset amount, supply a mixture solution obtained by the mixing unit to a measurement region in which a bioactive substance is immobilized in advance, and measure an interaction between the bioactive substance and the sample substance in the mixture solution based on a result of measuring a refraction index of a light incident on the measurement region.

Apparatus and method for measuring interaction between measurement-target sample substance and bioactive substance

An object of the present invention is to provide a method for measuring the dissociation rate coefficient (Kd) by surface plasmon resonance analysis without measuring the theoretical maximum amount of binding (Rmax). The present invention provides a method for measuring the dissociation rate coefficient (Kd) of the reaction between an analyte molecule immobilized on a metal surface and a molecule that interacts with the analyte molecule by assaying changes in surface plasmon resonance signals using a surface plasmon resonance measurement device, wherein the signal and the slope of the dissociation curve of the surface plasmon resonance signal curves, or the signal ratio are used to calculate the dissociation rate coefficient (Kd).

Method for measuring dissociation rate coefficient by surface plasmon resonance analysis

A method for producing biochemical analysis data includes the steps of collecting light selectively released from a plurality of light releasable regions two-dimensionally formed to be spaced apart from each other in a sample placed on a sample stage by a plurality of light guide member each of which is disposed to face one of the plurality of light releasable regions, leading the thus collected light to a light detector and photoelectrically detecting the light by the light detector. According to this method, it is possible to produce biochemical analysis data having high quantitative characteristics by photoelectrically detecting light emitted from a plurality of light releasable regions even in the case where the plurality of light releasable regions labeled with a labeling substance are formed in a sample at a high density.

Method for producing biochemical analysis data and apparatus used therefor

Flow channel member of sensor chip for biochemical analysis

Sensor chip for biochemical analysis

Growing community of inventors

Kanagawa, Japan

Nobuhiko Ogura