Nissan Chemical Industries Limited

Kyushu University

Nissan Chemical Corporation

Shizuoka University

Nobuhide Miyachi

Takehisa Iwama

Masahiro Goto

Takayuki Imoto

Masahiro Gotoh

Mikio Suzuki

Yoshio Ohara

Tatsuo Maruyama

Daisuke Koda

Hiroshi Iwasaki

Misao Miyamoto

Yoshinobu Yanagawa

Keigo Matsumoto

Ken-ichi Shikada

Tatsumi Ishihara

Tsubasa Kashino

Shigeru Mitsui

Masamichi Yamanaka

Keisuke Ohdoi

Takashi Yotsumoto

Takeshi Naito

Tetsuya Kobayashi

Katsuhiro Kato

A transdermally absorbable base material including: a lipid peptide compound including at least one of compound of Formula (1) below and the similar compounds or pharmaceutically usable salts thereof; a surfactant; a specific polyhydric alcohol; a fatty acid; and water, wherein Ris a Caliphatic group; Ris a hydrogen atom or a Calkyl group that optionally has a branched chain having a carbon atom number of 1 or 2; Ris a &#x2014;(CH)&#x2014;X group; n is a number of 1 to 4; and X is amino group, guanidino group, &#x2014;CONHgroup, or a 5-membered cyclic group optionally having 1 to 3 nitrogen atoms, a 6-membered cyclic group optionally having 1 to 3 nitrogen atoms, or a condensed heterocyclic group constituted by a 5-membered cyclic group and a 6-membered cyclic group which optionally have 1 to 3 nitrogen atoms.

Transdermally absorbable base material containing lipid peptide compound

There is provided a novel gelator containing a monourea derivative. A gelator comprising a compound of formula (1): wherein Ris a linear or branched alkyl group having a carbon atom number of 2 to 20, a cyclic alkyl group having a carbon atom number of 3 to 20, or a linear or branched alkenyl group having a carbon atom number of 12 to 20; and Ar is a Caryl group unsubstituted or optionally substituted with at least one substituent selected from the group consisting of a Calkyl group, a Calkoxy group, a Caryloxy group, a halogen atom, a nitro group, a phenyl group, a Calkylcarbonyl group, and a Caralkyl group.

Oil gelator

It is an object of the present invention to provide a cosmetic or external skin preparation that has an improved feel in use, e.g., excellent stretching on the skin surface, excellent permeation into the skin, and no stickiness, or crinkles. A cosmetic or an external skin preparation, and a medical instrument, comprising at least one lipid peptide-based gelator that contains a low-molecular lipid peptide of Formula (1): (where Rto Rare independently an organic group) or a pharmaceutically usable salt thereof.

Cosmetic, external skin preparation, and medical instrument

There is provided a gel sheet that has high biocompatibility and safety, can contain both a hydrophilic medicinal agent and a hydrophobic medicinal agent, and provides an excellent feel in use during the application onto human skin or others. A gel sheet including: a lipid peptide gelator including a low molecular weight lipid peptide having a molecular weight of 1,000 or less or a pharmaceutically usable salt of the lipid peptide; and a polymeric compound, wherein the polymeric compound is included in an amount of more than 1% (w/w) and less than 50% (w/w) with respect to the total mass of the gel sheet.

Gel sheet containing lipid peptide gelator and polymeric compound

There is provided a lithium-air secondary cell having an air electrode, a negative electrode containing metal lithium or a lithium-containing material and a gel-form solid electrolyte, wherein the gel-form solid electrolyte contains a solid electrolyte salt, a solvent, and a specific lipid peptide-type gelator composed.

Metal-air cell provided with gel-form solid electrolyte

A spray base material containing an aqueous medium that is gelled by a low-molecular gelator in the medium, wherein the low-molecular gelator includes one or more compounds selected from low-molecular compounds capable of gelling the aqueous medium via self-assembly.

Spray base material including low-molecular gelator

There is provided a gelator that is capable of forming a gel by an extremely small amount of addition in a wide pH range from acidic to alkaline regions, and a gel having high environmental compatibility, biocompatibility, and biodegradability. A gelator comprising: a lipid peptide of Formula (1) wherein Ris a Caliphatic group, Ris a hydrogen atom or a Calkyl group optionally having a Cbranched chain, Ris a &#x2014;(CH)&#x2014;X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, a &#x2014;CONHgroup, or a 5-membered ring optionally having 1 to 3 nitrogen atoms, a 6-membered ring optionally having 1 to 3 nitrogen atoms, or a fused heterocycle including a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms); or a pharmaceutically usable salt of the lipid peptide.

Lipid dipeptide and gel

A gelator that includes a lipid peptide of Formula (1) wherein Ris a Caliphatic group, Ris a hydrogen atom or a Calkyl group optionally having a Cbranched chain, Ris a &#x2014;(CH)&#x2014;X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, a &#x2014;CONHgroup, or a 5-membered ring optionally having 1 to 3 nitrogen atoms, a 6-membered ring optionally having 1 to 3 nitrogen atoms, or a fused heterocycle including a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms; or a pharmaceutically usable salt of the lipid peptide. 

There is provided a lipid peptide that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A lipid peptide represented by Formula (1): (where Rrepresents an aliphatic group having 9 to 23 carbon atoms;

Lipid peptide and hydrogel

There is provided a lipid peptide that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A lipid peptide represented by Formula (1): 

A hydrogel that includes an aqueous solution or an alcohol aqueous solution, and a hydrogelator containing a lipid peptide represented by Formula (1), or a pharmaceutically usable salt thereof. In Formula (1), Rrepresents an aliphatic group having 9 to 21 carbon atoms; R, R, and Rindependently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms that optionally has a branched chain having 1 or 2 carbon atoms, a phenylmethyl group, or a &#x2014;(CH)&#x2014;X group, and at least one of R, R, and Rrepresents a &#x2014;(CH)&#x2014;X group; n represents an integer from 1 to 4; and X represents an amino group, a guanidino group, a &#x2014;CONHgroup, or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms. 

Lipid tripeptide-based hydrogelator and hydrogel

There is provided a hydrogelator that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A hydrogelator comprising a lipid peptide represented by Formula (1): (where Rrepresents an aliphatic group having 9 to 21 carbon atoms;R, Rand Rindependently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atom(s) which may have a branched chain having 1 or 2 carbon atom(s), a phenylmethyl group or a &#x2014;(CH)&#x2014;X group, and at least one of R, Rand Rrepresents a &#x2014;(CH)&#x2014;X group; n represents the number of 1 to 4; X represents an amino group, a guanidino group, a &#x2014;CONHgroup or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which may have 1 to 3 nitrogen atom(s)) or a salt thereof, and a hydrogel comprising the hydrogelator.

The present invention provides novel pyridine type thiazolidines and their salts, expressed by the following formula (I): ##STR1##

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Tokyo, Japan

Nobuhide Miyachi