Asahi Glass Company, Limited

Santen Pharmaceutical Co., Ltd.

Nobuaki Mori

Yasushi Matsumura

Takashi Okazoe

Yoshitomi Morizawa

Shu-zhong Wang

Kazuhiro Ookura

Jiro Nishino

Takashi Nakano

Tadashi Nakajima

Eiichi Shirasawa

Hideshi Sasakura

Masaaki Kageyama

Toshihiko Kaminuma

Yasuhiro Yamada

Yuuichi Aoki

To provide a method for producing a 3-substituted 2-chloro-5-fluoro-pyridine or its salt in high yield from a readily available material through a short process under mild reaction conditions using a reagent which is easy for handling and simple in the reaction operation. Namely, a method for producing the following compound (2) or its salt which comprises selectively reducing a chlorine atom at the 6-position of the following compound (1) or its salt, is provided. Further, a method for producing the following compound (4) or its salt which comprises substituting a Zgroup of the following compound (2) or its salt obtained by the reduction reaction, by a Zgroup, is provided. Here, Zis &#x2014;COR, etc., and Ris a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an aralkyl group or a cycloalkyl group. Zis a group different from Zand is &#x2014;COR, etc., and Ris an alkyl group, an alkenyl group, an aryl group, an aralkyl group or a cycloalkyl group. 

Method for producing 3-substituted 2-chloro-5-fluoro-pyridine or its salt

The present invention provides processes for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate and an optical isomer of the (4E)-5-chloro-2-isopropyl-4-pentenoate, namely a process for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate represented by the following formula (4), which comprises reacting a compound represented by the following formula (2) in the presence of an aprotic solvent (II) with a base (II) and then with (1E)-1,3-dichloro-1-propene to give a compound represented by the following formula (3), and dealkoxycarbonylating either ester in the compound represented by the following formula (3), and a process for producing a (S)-(4E)-5-chloro-2-isopropyl-4-pentenoate represented by the following formula (5), which comprises optically resolving a (4E)-5-chloro-2-isopropyl-4-pentenoate represented by the formula (4) obtained by the above-mentioned process (wherein R is a lower alkyl group or an aralkyl group). 

Process for producing (4E)-5-chloro-2-isopropyl-4-pentenoate and optically active form thereof

Process for producing piperidinecarbinols

A process for producing a piperidinecarbinol represented by the general formula (2), which comprises reducing the trans isomer of a compound represented by the general formula (1):

A fluorine-containing prostaglandin derivative of the formula (1) (or a salt thereof) and a medicine containing it, particularly, a preventive or therapeutic medicine for an eye disease: ##STR1## wherein A is a vinylene group or the like, R.sup.1 is an aryloxyalkyl group or the like, R.sup.2 and R.sup.3 are hydrogen atoms or the like, and Z is OR.sup.4 (wherein OR.sup.4 is a hydrogen atom or an alkyl group) or the like.

Difluoroprostaglandin derivatives and their use

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Ichihara, Japan

Nobuaki Mori