Chugai Seiyaku Kabushiki Kaisha

Nobuaki Kato

Hiroharu Matsuoka

Noriaki Maruyama

Takenori Ishizawa

Tadakatsu Takahashi

Yukio Suzuki

Keiichiro Tsuji

Hiroshi Suzuki

Masahiko Mihara

Kenichi Akamatsu

Masateru Ohta

Kazutaka Tachibana

Mitsuaki Nakamura

Nobuhiro Ohi

Yasuhisa Takeda

Shin Shimaoka

Toshio Kuroki

Kazuya Nakagomi

Katushito Miyamoto

Hiromichi Nishina

There is provided a compound represented by the general formula (1): wherein Het represents an optional substituted heterocylic group Aand Aeach independently represent &#x2014;CH&#x2550;, etc.; Arepresents &#x2014;CH&#x2014;, etc.; Rrepresents a 4-fluorophenyl group, etc.; Rrepresents an alkyl group; n represents 0, 1 or 2, provided that when Aand Aboth are &#x2014;CH&#x2550;, Arepresents &#x2014;CH&#x2014; or &#x2014;SO&#x2014;, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.

Indole derivative having heterocycle and mono- or diazaindole derivative

A compound pf general formula (I):wherein, for example,

Antiandrogenic agent

There is provided a compound represented by the general formula (1):wherein Het represents an optional substituted heterocylic group Aand Aeach independently represent &#x2014;CH&#x2550;, etc.; Arepresents &#x2014;CH&#x2014;, etc.; Rrepresents a 4-fluorophenyl group, etc.; Rrepresents an alkyl group; n represents 0, 1 or 2, provided that when Aand Aboth are &#x2014;CH&#x2550;, Arepresents &#x2014;CH&#x2014; or &#x2014;SO&#x2014;, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.

Heterocyclic indole derivatives and mono- or diazaindole derivatives

Antirheumatic agent containing as an active ingredient a compound resented by the following general formula (II):

Methotrexate derivatives

Methotrexate derivative

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Gotenba, Japan

Nobuaki Kato