Other

Japan Tobacco Inc.

Toyo Seikan Kaisha, Ltd.

Amgen Fremont Inc.

Abgenix, Inc.

Nobuaki Hori

Krisztina M Zsebo

Claude Geoffrey Davis

Aya Jakobovits

Takashi Tsuji

Katsunari Tezuka

Hiroshi Takeda

Kazuo Sasaki

Minoru Tsuji

Takemasa Shiraishi

Teruhiko Matsumiya

Yutaka Oomura

Ava Jakobovits

Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety of biological reactions (for example, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.) associated with AILIM-mediated costimulatory signal (secondary signal) transduction. Furthermore, it has been revealed that the human monoclonal antibody is effective to treat and prevent various diseases associated with AILIM-mediated costimulatory signal transduction, being capable of inhibiting the onset and/or advancement of the diseases.

Methods of treating systemic lupus erythematosus with an antibody against costimulatory signal transduction molecule ailim

The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produce a desired hybrid cell. The methods of the invention are widely applicable to the production of proteins having two or more components.

Production of a multimeric protein by cell fusion method

Methods of treating an inflammatory disorder and prohibiting proliferation, cytokine production, and signal transduction with antibody against costimulatory signal transduction molecule AILIM

Human monoclonal antibody against a costimulatory signal transduction molecule AILIM

The present invention is to provide a drug for improvement of brain function which is effective to prevent from or to cure dementia such as Alzheimer's disease. The drug for improvement of brain function of this invention comprises leptin of mammals as an effective component wherefore has a superior effect in improvement of learning and memory.

Methods for improving brain function using leptin or analogs thereof

Production of multimeric protein by cell fusion method

The present invention provides a pump for pumping fluids, especially highly viscous fluids such as shampoo, from a main fluid container through a nozzle without unwanted dripping, plugging, or mess. A piston reciprocates in a pump chamber, creating positive and negative pressure alternately in the pump chamber. Positive pressure in the pump chamber initiates a discharge phase of operation, wherein the fluid in the pump chamber is forced from the pump chamber through a discharge valve. Negative pressure in the pump chamber causes both a back-suction phase and a suction phase of operation. Back-suction occurs in the pump chamber immediately following the discharge phase, drawing any fluid remaining in an exit passage back through the discharge valve into the pump chamber. The suction phase starts immediately after the discharge valve closes at the end of the back-suction phase. During the suction phase, the negative pressure in the pump chamber draws fluid from the main fluid container through the suction valve and into the pump chamber. A resilient spring member biases the suction valve into a closed position during periods of non-use, especially when the pressure in the main fluid container increases due to an increase in temperature. The strength of the resilient spring member is established at a value which maintains the suction valve closed until a predetermined negative pressure is established across it.

Pump with back suction phase

A liquid foam-discharging, squeezable bottle is disclosed, which has a twist cap screwed onto the vessel body, the twist cap being composed of an inner cap and outer cap. The inner cap has formed therein two independent fluid-passing mechanisms at about its central position and at a position adjacent thereto, respectively. One of the fluid-passing mechanism is a liquid foam-generating mechanism comprising a pipe-shaped member having a net screen on one end thereof, and the other functions as a check valve. The outer cap has engaged inside of the foam-discharging opening an adapter fully covered with a net screen on one end located nearer to the contents of the vessel. This vessel enables one to rapidly discharge a uniform, creamy liquid foam by simple squeezing operation and, if desired, the foam can be sprayed by using an adapter having a small-diameter nozzle.

Liquid foam-discharging, squeezable vessel

Growing community of inventors

Yokohama, Japan

Nobuaki Hori