Teijin Limited

Osaka Bioscience Institute

Noboru Yoshioka

Jun Suzuki

Yorimasa Suwa

Takami Arai

Katsutoshi Sakurai

Satoshi Sugiura

Masaaki Suzuki

Yasuyoshi Watanabe

Takaharu Tsutsumi

Akira Tanokura

Yumiko Watanabe

Takumi Satoh

Yosuke Kataoka

A compound represented by the Formula below, and an agent for the remedy of neural damage having the said compound as the active ingredient. [Here, G represents G1 shown below Rrepresents, hydrogen atoms and acyl groups, W represents single bonds and alkylenes, m represents 0 or 1, Rand Rrepresent hydrogen atoms, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, aromatic hydrocarbon groups and heterocyclic groups, and Rrepresents hydrogen atoms, acyl groups and alkoxycarbonyl groups. Arepresents, single bonds, &#x2014;O&#x2014;, &#x2014;NR&#x2014;, and &#x2014;S(&#x2550;O)&#x2014;, Aand Arepresent single bonds, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, heterocyclic groups and phenylene groups, and Arepresents single bonds, carbonyl groups and aliphatic hydrocarbon groups. Rand Rrepresent hydrogen atoms, alkyl groups, cycloalkyl groups, phenyl groups and heterocyclic groups. The previously mentioned functional groups may be substituted.]

Neuropathy improvers containing nitrogenous compounds as the active ingredient

The present invention provides a neurodegenerative disease therapeutic agent containing as its active ingredient a (15R)-isocarbacycline derivative indicated by the following formula [I] or a 15-deoxy-isocarbacycline derivative indicated by the following formula [III]:(wherein, Rrepresents a C-Calkylene group, and Rrepresents a hydrogen atom, a C-C, alkyl group or protective group); or,(wherein, Rand Rare the same as those defined in formula [I]).

Neuropathy remedies

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Hino, Japan

Noboru Yoshioka