Sanwa Kagaku Kenkyusho Co., Ltd.

Noboru Tomiya

Tsutomu Ishida

Shigeaki Yoshina

Hitoshi Noda

Masayasu Kurono

Kiichi Sawai

Yasuaki Kondo

Kenji Miura

Toshinao Usui

Ryoichi Unno

Hiromoto Kimura

Tsunemasa Suzuki

Motohide Hayashi

Keiko Yamamura

Manabu Sugimoto

Makoto Usami

Yoshiyuki Nagao

Yuji Sato

Yukiya Tanaka

Shigeyoshi Nakamura

Hidehumi Yamakawa

A multi-layered film preparation is disclosed having a drug-containing layer which contains at least one water-soluble high molecular weight compound as a main base material, a layer which is made difficult to dissolve in water and positioned at one side of the drug-containing layer and a powdery adhesive compound positioned at the other side of the drug-containing layer.

Multi-layered drug containing film preparation having powder adhesive

The invention provides a polypeptide of calcitonin analogue and use thereof. The polypeptide has such an amino acid sequence that proline-amide residue (Pro-NH.sub.2) at C-terminal of native eel calcitonin is substituted to a homoserine amide residue (Hse.multidot.NH.sub.2).

Calcitonin analogue and use thereof

The modified polypeptide compound of the present invention is represented by the following general formula ((SEQ ID NO: 2)-X):

Modified polypeptide compound with VIP-like activity

The invention relates to a hydantoin derivative, salt thereof, process for the preparation thereof, and medicine containing the derivative. The derivative is represented by the formula ##STR1## wherein M is --CONH--NHR.sup.1 group, --CONH--OR.sup.2 group, ##STR2## in which R.sup.1 is hydrogen atom, an alkyl group, an alkenyl group, a phenyl radical, a substituted phenyl group, a naphthyl radical, a substituted naphthyl group, a pyridyl radical, a furyl radical or a thienyl radical, R.sup.2 is a hydrogen atom, an alkyl group, a phenyl radical or a substituted phenyl group, R.sup.3 and R.sup.4 are the same or different independently, each being a phenyl radical, or an aralkyl group, or R.sup.3 may form a substituted or non-substituted C.sub.5-6 saturated heterocyclic ring together with R.sup.4 and a possible nitrogen or oxygen atom, R.sup.5 forms a substituted or non-substituted saturated heterocyclic ring together with R.sup.6 and a possible nitrogen or oxygen atom, R.sup.7 is a nitroxy radical or a heteroaryl group, .sub.m and .sub.n are an integer of 2 to 5, Q is a hydrogen atom or ##STR3## in which R.sup.8 and R.sup.9 are the same or different independently, each being a substituted or non-substituted alkyl group, or R.sup.8 may form a substituted or non-substituted C.sub.5-6 saturated heterocyclic ring together with R.sup.9 and a possible nitrogen or oxygen atom, .sub.r is an integer of 2 to 5, T and X are the same or different independently, each being a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or an alkylmercapto group, and Z is an oxygen or sulfur atom. The derivatives and salts thereof are useful for the treatment of complications of diabetes and circulatory diseases.

Hydantoin derivatives for treating complications of diabetes and

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Aichi, Japan

Noboru Tomiya