Kowa Company Limited

Noboru Shimizu

Seiichi Sato

Yasumi Uchida

Yoshinori Kyotani

Hiromichi Shigyo

Kiyoshi Kawamura

Masami Shiratsuchi

Masahiko Nagakura

Hisashi Kunieda

Toshihiro Akashi

Naotoshi Sawada

Tomio Ohta

Takashi Yamaguchi

Kimiyuki Shibuya

Tadaaki Ohgiya

Toshiaki Oda

Hiroyuki Ishiwata

Kazuhiro Onogi

Tsutomu Toma

Yoshio Takahashi

Katsumi Kawamine

Hiroshi Ishihama

Yukihiro Okuno

Mikio Fujii

Koji Nakamura

Haruo Otaki

Yutaka Yamamoto

An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.

Indole derivatives, salts thereof, and congestive heart failure

Anti-arteriosclerotic pyridyl or imidazolyl derivatives of

A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --O--CH.sub.2 --,

Aromatic aminoethanol compounds, and utilization thereof as

A benzopyran compound represented by the following ##STR1## wherein A represents a direct bond or the bond --CH.sub.2 --O--,

Dihydrobenzopyran compounds and pharmaceutical composition comprising

A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --0--CH.sub.2--,

Certain phenyl or pyridyl-propanol-amines containing alkyl-nitrate

Isoindoline derivatives of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R represents a moiety selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, nitro, hydroxy and hydroxy lower alkyl, and n is a positive number from 1 to 3, which R's may be the same or different when n is 2 or 3, and when n is 2, the two R's may be joined to the carbon atom vicinal to the phenyl ring to which the two R's are joined and may taken together form lower alkylenedioxy and the group ##STR2## and R.sub.1 is a member of the group consisting of hydrogen and lower alkyl. The compounds of this invention can be readily prepared by reacting a compound of the formula ##STR3## wherein R represents, in addition to the above defined, alkoxycarbonyloxy; R.sub.1 and n are as defined above; and X is halogen or the groups --O--SO.sub.2 --Y where Y is either lower alkyl or aryl, with isoindoline of the formula ##STR4## or a minemal acid salt thereof. The compounds are useful in such fields as, for example cardiovascular drugs.

Isoindoline derivatives and the acid addition salts thereof and process

Growing community of inventors

Higashimurayama, Japan

Noboru Shimizu