Japan Tobacco Inc.

Amgen Inc.

Other

Yoshitomi Pharmaceutical Industries, Ltd.

Noboru Furukawa

Steven Marc Rubenstein

Masahiro Tanaka

Hiroshi Okamoto

Lawrence R McGee

Hisashi Shinkai

Atsushi Hagiwara

Jonathan B Houze

Frank Kayser

Takashi Inaba

Dustin L McMinn

Xiaolin Hao

Marc Labelle

Brian M Fox

Kexue Li

Simon Mark Jackson

Itsuo Uchida

Jian Zhang

Akira Saito

Junichi Haruta

Mutsuyoshi Matsushita

Atsuhito Yoshida

Yasuo Urata

Katsuyoshi Hara

Koretake Anami

Shoichi Sagawa

Kiyosei Iio

Kunio Iwata

Kazuyuki Sugimoto

Takuya Matsui

Akihiro Yasuda

Nobuya Ogawa

Masahiro Suzuki

Guosen Ye

Hiroaki Hari

Shoji Hoshino

Lawrence R Mcgee

Steven M Rubenstein

Hitoshi Kawamura

Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPAR&#x3b3;. In particular, the compounds of the invention modulate the function of PPAR&#x3b3;. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.

Quinolinyl and benzothiazolyl modulators

Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the activity of proteins involved in lipid metabolism and cell proliferation.

Fused bicyclic nitrogen-containing heterocycles

Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PAPAR&ggr;. In particular, the compounds of the invention modulate the function of PAPAR&ggr;. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.

Novel peptide derivatives of the following formula ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable acid addition salts thereof and analogous copounds thereof. Since the derivatives and their pharmaceutically acceptable acid addition salts of the present invention possess stronger actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, signal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.

Histidyl peptide derivatives

Growing community of inventors

Osaka, Japan

Noboru Furukawa