Patients Pending Ltd.

Cardiosert Ltd.

G-sense Ltd.

Biosert Ltd.

Microbot Medical Ltd.

Noam Peleg

Avraham Shekalim

A sliding cover for a liquid delivery device, such as a cap () for a pen injector (), incorporates a set of sensors including an optical sensor () with an output which changes during uncapping or capping motions on passing of a plunger () of the pen injector. This output is used together with a position sensor () to determine the position of the plunger along a cylinder () of the liquid delivery device. By monitoring changes in the plunger position, the quantity of dosages delivered by the liquid delivery device can be determined, displayed, stored and/or transmitted to an external device for further data processing or storage. Preferred implementations of the invention employ optical sensors with a converging beam (), and/or position sensors employing linear potentiometer strips ().

Cover for liquid delivery system with integrated plunger position sensing using focused optical beam and linear potentiometer

A double guide wire includes two guidewires deployed concentrically, one within the other. Each guidewire is formed as an elongated flexible shaft having a distal portion including a deflectable helical coil terminating at a distal tip. The first guidewire is implemented as a hollow guidewire having a central lumen extending along its length, while the second guidewire is configured as a smaller gauge guidewire deployed within the central lumen of the first guidewire. An adjuster mechanism allows the inner guidewire to be advanced and retracted relative to the outer guidewire, transforming the guidewire between: a first state in which the distal tip of the second guidewire is adjacent to the distal tip of the first guidewire; and a second state in which at least part of the distal portion of the inner guidewire is advanced beyond the distal tip of the first guidewire.

Double concentric guidewire

A pressure-measuring guidewire system includes a hollow guidewire () in sealed interconnection with a contained volume () of a connector (). The contained volume is bordered on at least one side by a septum (). A pressure sensor unit () includes a transducer () associated with a hollow needle () which can be inserted to penetrate the septum (), thereby connecting the transducer with a column of fluid within an inner lumen of the guidewire (). Priming of the guidewire is performed prior to use, typically by use of a syringe, prior to connection of the sensor unit, thereby protecting the transducer from damage from the priming pressure. Also disclosed is a guidewire tip configuration which provides effective fluid connection for pressure measurement while maintaining the properties of a conventional guidewire.

Guidewire system for intra-vascular pressure measurement

A compound stent device includes a first stent portion and a second stent portion, where the second stent portion is formed from a biodegradable material, and the first stent portion is formed from either non-biodegradable material or is biodegradable significantly more slowly than the second portion. The compound stent device is deformable from a first diameter to a second larger diameter. Immediately after expansion, the first stent portion and the second stent portion cooperate to provide a first contact area of support for a length of a surrounding vessel. After decomposition of the second stent portion, the first stent portion provides a second contact area of support for the length of the surrounding vessel which is at least 10 percent smaller than the first contact area.

Expanding stent

A guidewire assembly having selectively adjustable stiffness and tip curvature includes a hollow guidewire having a distal portion terminating at a distal tip, a curvature-modifying element anchored to the distal tip, and a stiffness-modifying element displaceable within the hollow guidewire towards and away from the distal tip so as to vary a stiffness of the distal portion. The stiffness-modifying element and the curvature-modifying element are frictionally linked such that movement of the stiffness-modifying element from a current position over a first range of motion causes corresponding displacement of the curvature-modifying element, thereby modifying a state of curvature of at least part of the distal portion of the guidewire. Movement of the stiffness-modifying element beyond the first range of motion displaces the stiffness-modifying element relative to the curvature-modifying element.

Guidewire having selectively adjustable stiffness and tip curvature

A metabolite monitoring system comprising a microdialysis probe including a semi-permeable membrane and a probe flow path passing from an inlet through a sensing volume adjacent to said semi-permeable membrane to an outlet, a fluid delivery device for delivering dialysate to said inlet; and a metabolite monitoring system associated with said outlet for monitoring a concentration of at least one metabolite in said dialysate from said microdialysis probe, wherein said fluid delivery device is configured to deliver a pulsed flow of said dialysate to said inlet.

Growing community of inventors

Gan Ner, Israel

Noam Peleg