University of Pennsylvania

The United States Government As Represented by the Department of Veterans Affairs

Monell Chemical Senses Center

Noam A Cohen

Bert W O'Malley, Jr

Danielle Reed

Robert J Lee

Alexander G Chiu

James N Palmer

Jacob D Steiger

The invention provides methods and compositions for the diagnosis, prognosis and treatment of respiratory tract diseases. Specifically, the invention provides diagnosis, prognosis and treatment of respiratory infections using bitter and sweet taste signal transduction pathways. In one aspect, the invention relates to a method for treating a respiratory infection by administering a composition to the respiratory tract of a subject in an amount capable of activating bitter taste signaling and/or inhibiting sweet taste signaling. The composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract. In another aspect, the invention relates to a composition for treatment of a respiratory infection. Such composition comprises at least a bitter receptor agonist and, optionally, a pharmaceutically acceptable carrier for delivering the composition to the respiratory tract.

Diagnosis and treatment for respiratory tract diseases

This invention relates to methods and compositions capable of inhibiting biofilm formation. Specifically, provided herein are methods and compositions using Lactoferrin for the inhibition of biofilm formation.

Biofilm prevention using lactoferrin

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Bala Cynwyd, PA, United States of America

Noam A Cohen