Hoffmann-la Roche Inc.

Noal Cohen

Gabriel G Saucy

Michael Rosenberger

Giuseppe Federico Weber

Keith A Yagaloff

Ferdinand K Lee

Andrzej Robert Daniewski

Guiseppe F Weber

The invention relates to compounds selected from the group consisting of the formulas: ##STR1## wherein R.sup.2 and Ph are as described herein. These compounds are potent leukotriene B.sub.4 antagonists and are therefore useful in the treatment of inflammatory diseases.

Carboxylic acid Leukotriene B4 antagonists

Compounds of the formula ##STR1## wherein X is O or CH.sub.2 ; Y is O, --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, or --OCH.sub.2 C.sub.6 H.sub.4 --;

Carboxylic acid leukotriene B.sub.4 antagonists

Compounds of the formula ##STR1## wherein X is O or CH.sub.2 ;

Carboxylic acid leukotriene B4 antagonists

A process for producing alpha-tocopherol and intermediates in this process.

Process for producing vitamin E

Vitamin E intermediate

Novel 2-halochromans and their coupling to various nucleophiles to produce Vitamin E and as well as novel intermediates for Vitamin E.

2-allylchromans

Chromanemelonate esters

The invention relates to compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2 is hydrogen or halogen; R.sup.3, R.sup.4 and R.sup.5 are hydrogen, acyl or lower alkyl; R.sup.6 and R.sup.7, independently, are hydrogen or lower alkyl; X is alkylene.sub.3-7 ; and n is an integer of zero to four; provided that only one of R.sup.3, R.sup.4 or R.sup.5 can be acyl; enatiomers thereof, and, when R.sup.7 is hydrogen, salts thereof with pharmaceutically acceptable bases. The compounds of formulas I and II are useful as agents for the treatment of allergic conditions.

3,4-dihydro-2H-1-benzopyran derivatives

The invention relates to compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2 is hydrogen or halogen; R.sup.3, R.sup.4 and R.sup.5 are hydrogen, acyl or lower alkyl; R.sup.6 and R.sup.7, independently, are hydrogen or lower alkyl; X is alkylene.sub.3-7 ; and n is an integer of zero to four; provided that only one of R.sup.3, R.sup.4 or R.sup.5 can be acyl; enantiomers thereof, and, when R.sup.7 is hydrogen, salts thereof with pharmaceutically acceptable bases. The compounds of formulas I and II are useful as agents for the treatment of allergic conditions.

2-halochromans

The invention relates to compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkyl, R.sup.2 is hydrogen or halogen, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is hydrogen or lower alkyl, R.sup.5 is hydrogen, lower alkyl or aralkyl, X is alkylene and n is an integer from 1 to 6, enantiomers thereof, and, when R.sup.5 is hydrogen, salts thereof with pharmaceutically acceptable bases.

4-oxo-3,4-dihydro-2H-1-benzopyranyloxy alkanoic acid derivatives

Methyl derivatives of arachidonic acid and intermediates thereto have been synthesized. These derivatives are inhibitors of SRS-A synthesis and are useful for treating and preventing allergic reactions.

Inhibitors of SRS-synthesis

A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, .beta.-hydroxy-isobutyric acid including intermediates in this synthesis.

Growing community of inventors

Montclair, NJ, United States of America

Noal Cohen